The effect of melatonin in patients with polycystic ovary syndrom

The effect of melatonin supplemention for ovarian stimulation cycles on sleep and mood and microinjection outcomes in patients with polycystic ovary syndrom

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160717028967N10

Enrollment

Registered

2019-06-07

Start date

2019-05-22

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Poly Cystic Ovary Syndrome. Poly cystic ovarian syndrome

Interventions

Intervention 1: Intervention group: Melatonin 3 mg tablets (nature made company) daily with oral contraceptive pill and Folic Acid start from the third day of the menstrual cycle before stimulation of

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age between 20 to 40 years old Having symptoms of polycystic ovary syndrome candidate of micro-injection for infertility treatment

Exclusion criteria

Exclusion criteria: Azospermia in sperm analysis of male partner The use of alternative infertility treatment services Uncontrolled medical condition Abnormal karyotype Uterine abnormal anatomy Immune and coagulation dysfunction

Design outcomes

Primary

Measure	Time frame
Number of retrieved oocytes. Timepoint: on the day of oocyte pick up. Method of measurement: Microscopic Assessment of oocytes count by the embryologist.;Fertilization rate. Timepoint: The fertilization rate will be checked on the day after sperm injection. Method of measurement: Is calculated as percentage transformation of micro injected oocytes in to two pronuclei.;Number of embryos. Timepoint: The time of the assessment is 3 days after fertilization. Method of measurement: Microscopic assessment of the embryes count by the embryologist.;Sleep. Timepoint: Before the intervention and after 6 weeks. Method of measurement: Pittsburgh sleep quality index questionnaire,STOP Bang questionnaire and insomnia severity index questionnair.;Depression. Timepoint: Before the intervention and after 6 weeks. Method of measurement: Beck depression short Inventory.;Quality of retrieved oocytes. Timepoint: on the day of oocyte pick up. Method of measurement: Microscopic assessment of the oocytes morphology by the embryologist.;Quality of embryos. Timepoint: The time of the assessment is 3 days after fertilization. Method of measurement: Microscopic assessment of the embryes morphology by the embryologist.	—

Measure

Time frame

Number of retrieved oocytes. Timepoint: on the day of oocyte pick up. Method of measurement: Microscopic Assessment of oocytes count by the embryologist.;Fertilization rate. Timepoint: The fertilization rate will be checked on the day after sperm injection. Method of measurement: Is calculated as percentage transformation of micro injected oocytes in to two pronuclei.;Number of embryos. Timepoint: The time of the assessment is 3 days after fertilization. Method of measurement: Microscopic assessment of the embryes count by the embryologist.;Sleep. Timepoint: Before the intervention and after 6 weeks. Method of measurement: Pittsburgh sleep quality index questionnaire,STOP Bang questionnaire and insomnia severity index questionnair.;Depression. Timepoint: Before the intervention and after 6 weeks. Method of measurement: Beck depression short Inventory.;Quality of retrieved oocytes. Timepoint: on the day of oocyte pick up. Method of measurement: Microscopic assessment of the oocytes morphology by the embryologist.;Quality of embryos. Timepoint: The time of the assessment is 3 days after fertilization. Method of measurement: Microscopic assessment of the embryes morphology by the embryologist.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Soheila Ansaripour

Avecinna infertility center

Soh.ansaripour@gmail.com+98 21 23519

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026