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Effect of treatment protocol on pregnancy outcome in infertile poor ovarian responder women undergoing in vitro fertilization/ intra cytoplasmic sperm injection (IVF/ ICSI)

Clinical trail of comparison of pregnancy outcome in delay gonadotropin releasing hormone(GnRH) antagonist versus microdose flare GnRH agonist protocol in infertile poor ovarian responder women undergoing in vitro fertilization/ intra cytoplasmic sperm injection (IVF/ ICSI) cycles

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016071628950N1
Enrollment
100
Registered
2016-10-20
Start date
2016-09-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility ,unspecified

Interventions

Intervention 1: In interventional group delay Gn RH antagonist protocol for controlled ovarian hyper stimulation is used. All patients are received estrogen tablet 2 milligram daily starting in mid lu
Treatment - Drugs
In interventional group delay Gn RH antagonist protocol for controlled ovarian hyper stimulation is used. All patients are received estrogen tablet 2 milligram daily starting in mid luteal previous cy
In control group, microdose flare Gn RH agonist protocol for controlled ovarian hyperstimulation is used.On the second day of menstrual cycle Buserlin acetate (Cinnafact, Cinnagen) 50 micro gram twice

Sponsors

Vice chancellor for research, Shahid Sadoughi University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 42 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: infertile women between 18 to 42 years old with =8 antral follicle count in bilateral ovaries; and or patients with basal follicle stimulating hormone (FSH) = 9 milli unit per milliliter; and or patients with a history of cancelled invitro fertilization(IVF) cycle =3 dominant follicles; and or =500 pico mole per liter estradiol (E2) levels at human chorionic gonadotropin( hCG) administration day. Exclusion criteria: patients under 18 years old or over 42 years old; patients with sever male factor

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy. Timepoint: 28 days after transfer. Method of measurement: Vaginal sonography.

Secondary

MeasureTime frame
Number of mature oocytes. Timepoint: Oocyte pucture day. Method of measurement: Number of M2 oocytes.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDR Nosrat Neghab

Yazd Research and Clinical Center for Infertility Shahid Sadoughi University of Medical Sciences

nosrat20@yahoo.com; nosratneghab@ssu.ac.ir+98 35 3824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026