The effects of propofol and ketmine-propofol on hemodynamic changes and recovery time in patients under cataract surgery

Comparison of the effect of propofol and ketmine-propofol on hemodynamic changes and recovery time in patients under cataract surgery: A clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016071328912N1

Enrollment

100

Registered

2016-11-04

Start date

2016-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cataract. Disorders of lens

Interventions

Intervention 1: The intervention: Ketamine 0.25 mg per kg in a volume of 2 mL and propofol infusion. Intervention 2: Control group: placebo saline in a volume of 2ml and propofol infusion.

Treatment - Drugs

The intervention: Ketamine 0.25 mg per kg in a volume of 2 mL and propofol infusion

Control group: placebo saline in a volume of 2ml and propofol infusion

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with cataract; ASA Classes one and two Exclusion criteria:Sensitivity to drugs ketamine and propofol; severe drug side effects; history of chronic disease; opium addiction.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Diastolic Blood Pressure. Timepoint: Before injection, every 2 minutes to 10 minutes after the injection and then every 5 minutes until completion of the operation and transfer to department. Method of measurement: In millimeters of mercury using mercury sphygmomanometer.;Systolic Blood Pressure. Timepoint: Before injection, every 2 minutes to 10 minutes after the injection and then every 5 minutes until completion of the operation and transfer to department. Method of measurement: In millimeters of mercury using mercury sphygmomanometer.;Artrial Oxygen Saturation. Timepoint: Before injection, every 2 minutes to 10 minutes after the injection and then every 5 minutes until completion of the operation and transfer to department. Method of measurement: Based on the percentage using pulse oximetry.;Pulse rate. Timepoint: Before injection, every 2 minutes to 10 minutes after the injection and then every 5 minutes until completion of the operation and transfer to department. Method of measurement: Based on pulse per minute using cardiac monitoring.;Recovery Time. Timepoint: Before injection, every 2 minutes to 10 minutes after the injection and then every 5 minutes until completion of the operation and transfer to department. Method of measurement: Visual Scale Alertness.	—

Measure

Time frame

Diastolic Blood Pressure. Timepoint: Before injection, every 2 minutes to 10 minutes after the injection and then every 5 minutes until completion of the operation and transfer to department. Method of measurement: In millimeters of mercury using mercury sphygmomanometer.;Systolic Blood Pressure. Timepoint: Before injection, every 2 minutes to 10 minutes after the injection and then every 5 minutes until completion of the operation and transfer to department. Method of measurement: In millimeters of mercury using mercury sphygmomanometer.;Artrial Oxygen Saturation. Timepoint: Before injection, every 2 minutes to 10 minutes after the injection and then every 5 minutes until completion of the operation and transfer to department. Method of measurement: Based on the percentage using pulse oximetry.;Pulse rate. Timepoint: Before injection, every 2 minutes to 10 minutes after the injection and then every 5 minutes until completion of the operation and transfer to department. Method of measurement: Based on pulse per minute using cardiac monitoring.;Recovery Time. Timepoint: Before injection, every 2 minutes to 10 minutes after the injection and then every 5 minutes until completion of the operation and transfer to department. Method of measurement: Visual Scale Alertness.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSheida Ebrahimi

Islamic Azad University of Shahroud

sheida.ebrahimi68@yahoo.com+98 23 3239 6714

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026