Nephrolithiasis (kidney Stones). Calculus of kidney
Conditions
Interventions
Intervention 1: Intervention group: Sankol oral drop (60 drops, three times daily). Each ml of Sankol contains extracts of Foeniculum vulgare (250 mg), Laurus nobilis (125 mg), Tribulus terrestris (12
Sponsors
Goldaru Pharmaceutical Company
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients ( over 18 years old) Patients with normal renal function, defined as eGFR > 60 mL/min/1.73 m² Definitive diagnosis of nephrolithiasis confirmed by ultrasonography Patients diagnosed with urolithiasis who are actively passing a stone and presenting with renal colic Upon obtaining informed consent and agreement to participate
Exclusion criteria
Exclusion criteria: Patients with cystine or struvite stones will be excluded from the study Failure to adhere to treatment protocols and incorrect use of medications Development of serious adverse effects or allergic reactions to the study medication Lack of follow-up and inability to contact the patient for future evaluations Patient’s decision to withdraw from the study Presence of chronic diseases including active malignancy, chronic liver disease, or heart failure Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in kidney or ureteral stone size. Timepoint: At baseline and at the end of treatment (after 3 months). Method of measurement: Measured using ultrasound imaging and recorded in millimeters.;Change in the number of kidney or ureteral stones. Timepoint: At baseline and at the end of treatment (3 months or upon stone expulsion). Method of measurement: Assessed by ultrasound imaging and recorded as count.;Duration of stone expulsion. Timepoint: From start of treatment until complete stone expulsion. Method of measurement: Self-reported by patient and confirmed by ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Daily water intake. Timepoint: Recorded weekly throughout the treatment period. Method of measurement: Self-reported by the patient using a daily intake log.;Presence of a family history of kidney stones. Timepoint: Collected at baseline. Method of measurement: Patient interview and medical history questionnaire.;Frequency of previous kidney stone episodes. Timepoint: Collected at baseline. Method of measurement: Patient history and medical record review.;History of surgical interventions for kidney stones. Timepoint: Collected at baseline. Method of measurement: Medical history interview and documentation.;Current medications for kidney or urinary tract stones. Timepoint: Assessed at baseline and monitored during follow-up. Method of measurement: Medication history interview and review of prescriptions. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShirin Sadat Badri
Esfahan University of Medical Sciences
Outcome results
None listed