Kidney failure. Acute kidney failure
Conditions
Interventions
Intervention 1: Intervention group: For people in the intervention group, colistin will be prescribed as a long-term infusion (6 hours). People who, for any reason, received the drug colistin with a s
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Age 18 to 50 years Receiving colistin at a dose of 4.5 million units every 12 hours (or an equivalent dose according to the patient's kidney function) Creatinine clearance above 50 ml/min at the beginning of the study No history of acute kidney injury (based on history and medical history) Failure to receive other nephrotoxic drugs such as aminoglycosides, amphotericin B, cyclosporine, tacrolimus, furosemide and NSAIDs Not receiving other antioxidant supplements such as vitamins C and E
Exclusion criteria
Exclusion criteria: Recent use of colistin in the last 7 days Using colistin for less than 3 days Dialysis before starting treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine level (SCr). Timepoint: before starting the treatment, during the treatment for one day in between and also 12 hours after the last dose of colistin on the tenth day of treatment with this antibiotic (before receiving any other dose of colistin). Method of measurement: Hospital laboratory.;Blood urea nitrogen (BUN). Timepoint: before starting the treatment, during the treatment for one day in between and also 12 hours after the last dose of colistin on the tenth day of treatment with this antibiotic (before receiving any other dose of colistin). Method of measurement: Hospital laboratory.;Creatinine clearance (CrCl). Timepoint: before starting the treatment, during the treatment for one day in between and also 12 hours after the last dose of colistin on the tenth day of treatment with this antibiotic (before receiving any other dose of colistin). Method of measurement: calculating by equation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShirinsadat Badri
Esfahan University of Medical Sciences
Outcome results
None listed