Vancomycin dosing in treatment of meningitis

Comparison of effect of administration of vancomycin by continuous infusion versus intermittent infusion on concentration of vancomycin in the CSF in postneurosurgical meningitis patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016071114693N6

Enrollment

Registered

2016-10-08

Start date

2015-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postneurosurgical meningitis. Pneumococcal meningitis, Streptococcal meningitis

Interventions

Intervention 1: vancomycin, 25 mg/kg Q12H, intermittent infusion, twice daily, for 21 days. Intervention 2: vancomycin, 50mg/kg, continuous infusion, for 21 days.

Treatment - Drugs

vancomycin, 25 mg/kg Q12H, intermittent infusion, twice daily, for 21 days

vancomycin, 50mg/kg, continuous infusion, for 21 days

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: (Inclusion criteria: patients who diagnosed postneurosurgical meningitis and received vancomycin; Age>18 years old) (Exclusion criteria: chronic kidney disease (creatinine clearance30mcg/mL)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
CSF vancomycin concentration. Timepoint: day 3 and day 5 of treatment. Method of measurement: mcg/mL, Fluorescent PolarizationImmunoassay, by Cobas system.;Serum concentration of vancomycin. Timepoint: day 3 and 5 of treatment. Method of measurement: mcg/mL, Fluorescent PolarizationImmunoassay, by Cobas system.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Taheri Morteza

Shahid Beheshti University of Medical Sciences

morteza.taheri83@yahoo.com+98 21 2243 9770

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026