myocardial injury. Other functional disturbances following cardiac surgery
Conditions
Interventions
Intervention 1: Intervention group: An infusion of dexmedetomidine (0.3 - 0.5 µ/kg/h) after induction for 24 hours. Intervention 2: Contrl group: An infusion of normal salin((0.3 - 0.5 µ/kg/h) after i
Treatment - Drugs
Intervention group: An infusion of dexmedetomidine (0.3 - 0.5 µ/kg/h) after induction for 24 hours
Contrl group: An infusion of normal salin((0.3 - 0.5 µ/kg/h) after induction for 24 hours
Sponsors
Vice chancellor for research of Guilan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Isolated and elective CABG surgery; Age 35 to 65 years old; 3 or 4 coronary artery stenosis; EF>45%;Normal sinus rhythm and normal heart rate; myocardial enzymes troponin and CK-MB levels before surgery in normal range; Exclusion criteria:Heart Rate<50; SBP<90 mmHg;Thyroid dysfunction uncontrolled diabetes; History of corticosteroid therapy; addiction
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of CK-MB. Timepoint: Before anesthesia(T0); 6 hr post surgery(T1); 12 hrs post surgery (T2) ; 24 hrs post surgery (T3) ;48 hrs post surgery (T4). Method of measurement: Immunoassay.;Serum Cortisol level. Timepoint: Before anesthesia(T0); 6 hr post surgery(T1); 12 hrs post surgery (T2) ; 24 hrs post surgery (T3) ;48 hrs post surgery (T4). Method of measurement: Immunoassay. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of Troponin I. Timepoint: Before anesthesia(T0); 6 hr post surgery(T1); 12 hrs post surgery (T2) ; 24 hrs post surgery (T3) ;48 hrs post surgery (T4). Method of measurement: immunoassay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAbbas Sedighinejad
Guilan University of Medical Sciences
Outcome results
None listed