Calorie restriction and plasma brain-derived neurotrophic factor

Effect of calorie restriction on blood pressure and plasma brain-derived neurotrophic factor in overweight or obese subjects

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160702028742N11

Enrollment

Registered

2022-01-29

Start date

2022-02-19

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension. Essential (primary) hypertension

Interventions

Intervention group: Low-calorie diet.

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with a body mass index higher than 25 Regular use of antihypertensive drugs for at least the last 3 months non-smoker Haven't been under any weight-loss diet at least 3 months before participating in the study

Exclusion criteria

Exclusion criteria: Taking antipsychotic, anticonvulsant drugs Cancer or stage 4 or 5 chronic or kidney disease Pregnancy or breastfeeding Any changes in the disease treatment plan during the study, including changes in the type and dose of drugs used to affect blood pressure or surgery• Insulin treated patients Taking omega 3 supplement

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Baseline and the end of study. Method of measurement: Validated digital arm sphygmomanometer.	—

Secondary

Measure	Time frame
Plasma brain-derived neurotrophic factor. Timepoint: Baseline and the end of study. Method of measurement: ?»]??.;Plasma ICAM-1. Timepoint: Baseline and the end of study. Method of measurement: ELISA.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavad Nasrollahzadeh

Shahid Beheshti University of Medical Sciences

jnasrollahzadeh@gmail.com+98 21 2207 7424

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026