overweight and obesity. overweight and obesity
Conditions
Interventions
Intervention 1: Intervention group: Overweight or obese people who have been regularly taking statins before starting the study are put on a healthy low-calorie diet. Intervention 2: Control group: Ov
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: BMI>25 kg/m2 No weight change of more than 1-2 kg in the past month LDL-C less than 130 mg/dL Taking statins for more than 2 months (participants in the statin group)
Exclusion criteria
Exclusion criteria: chronic chronic kidney disease (Cr> 1.4 mg / dl), cancer, autoimmune or inflammatory diseases treated with corticosteroids Pregnancy and lactation Regular use of garlic pills, omega-3 supplements, or flaxseed Changes in medications during the study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma total cholesterol to HDL-cholesterol ratio. Timepoint: Baseline and after 2 months. Method of measurement: Enzymatic. | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma LDL-C. Timepoint: Baseline and after 2 moths. Method of measurement: Enzymatic.;Plasma TG. Timepoint: Baseline and after 2 moths. Method of measurement: Enzymatic.;CRP. Timepoint: Baseline and after 2 moths. Method of measurement: Turbidometry.;IL-6. Timepoint: Baseline and after 2 moths. Method of measurement: ELISA.;Plasminogen activator inhibitor-1. Timepoint: Baseline and after 2 moths. Method of measurement: ELISA.;Apolipoprotein B. Timepoint: Baseline and after 2 moths. Method of measurement: Turbidometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactJavad Nasrollahzadeh
Shahid Beheshti University of Medical Sciences
Outcome results
None listed