The effect of Low –dose ketamine to prevent hypotension due to positioning after induction of general anesthesia in lumbar discectomy

Clinical Trial of The Effect of Low Dose Ketamine to Prevent Hypotension While Changing Position After Induction of Anesthesia in Patients Undergoing Lumbar Discectomy

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016062726328N2

Enrollment

Registered

2016-08-25

Start date

2016-06-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension. Complications of medical and surgical care

Interventions

Intervention 1: Intervention by drug includes ketamine 0.5 mg/kg 1.5 minutes before positioning of the patient from supine to prone. Intervention 2: In control group Normal Saline with the same vol

Treatment - Drugs

Intervention by drug includes ketamine 0.5 mg/kg 1.5 minutes before positioning of the patient from supine to prone

In control group Normal Saline with the same volume will be used 1.5 minutes before positioning of the patient from supine to prone position

Eligibility

Sex/Gender

All

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients candidated for Lumbar Discectomy, Age between 20 to 40 year with ASA(American Society of Anesthesiologists) Class I, Exclusion Criteria: History of Cardiovascular Drugs usage, Emergency Procedures, Body Mass Index more than 40

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Diastolic Blood Pressure. Timepoint: Preoperative , Pre Intubation , one minute after Intubation , before Positioning , Immediately after Positioning the Patient from Supine to Prone Position , then every 2 minute until 10 minutes after Positioning. Method of measurement: mmHg using Non Invasive Blood Pressure Technique by Monitoring Device.;Mean Arterial Pressure. Timepoint: Preoperative , Pre Intubation , one minute after Intubation , before Positioning , Immediately after Positioning the Patient from Supine to Prone Position , then every 2 minute until 10 minutes after Positioning. Method of measurement: mmHg using Non Invasive Blood Pressure Technique by Monitoring Device.;Systolic Blood Pressure. Timepoint: Preoperative , Pre Intubation , one minute after Intubation , before Positioning , Immediately after Positioning the Patient from Supine to Prone Position , then every 2 minute until 10 minutes after Positioning. Method of measurement: mmHg using Non Invasive Blood Pressure Technique by Monitoring Device.;Heart Rate. Timepoint: Preoperative , Pre Intubation , one minute after Intubation , before Positioning , Immediately after Positioning the Patient from Supine to Prone Position , then every 2 minute until 10 minutes after Positioning. Method of measurement: Beat/min.	—

Measure

Time frame

Diastolic Blood Pressure. Timepoint: Preoperative , Pre Intubation , one minute after Intubation , before Positioning , Immediately after Positioning the Patient from Supine to Prone Position , then every 2 minute until 10 minutes after Positioning. Method of measurement: mmHg using Non Invasive Blood Pressure Technique by Monitoring Device.;Mean Arterial Pressure. Timepoint: Preoperative , Pre Intubation , one minute after Intubation , before Positioning , Immediately after Positioning the Patient from Supine to Prone Position , then every 2 minute until 10 minutes after Positioning. Method of measurement: mmHg using Non Invasive Blood Pressure Technique by Monitoring Device.;Systolic Blood Pressure. Timepoint: Preoperative , Pre Intubation , one minute after Intubation , before Positioning , Immediately after Positioning the Patient from Supine to Prone Position , then every 2 minute until 10 minutes after Positioning. Method of measurement: mmHg using Non Invasive Blood Pressure Technique by Monitoring Device.;Heart Rate. Timepoint: Preoperative , Pre Intubation , one minute after Intubation , before Positioning , Immediately after Positioning the Patient from Supine to Prone Position , then every 2 minute until 10 minutes after Positioning. Method of measurement: Beat/min.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactParish Masoud

Tabriz University of Medical Sciences

parishm@tbzmed.ac.ir; masoudparish@yahoo.com; artin1393.ap@gmail.com+98 41 3385 5842

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026