Migraine. Migraine without aura
Conditions
Interventions
Intervention 1: Intervention group: Nano-curcumin receiver group, two 40 mg capsules per day Nano-curcumin after breakfast, for 2 months, made by Sina curcumin Iran. Intervention 2: Control group: Pla
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Age = 20 to 50 (y) 25<= Body Mass Index (kg/m2) =< 35 Diagnosis of episodic migraine without aura, according to IHS criteria by neurologist Voluntary cooperation of patients
Exclusion criteria
Exclusion criteria: use of dietary, vitamins and antioxidant supplements (such as curcumin) at least 4-6 weeks before the intervention Following special diets or special and intense physical activity at the last 3 months before the intervention Having comorbidity such as kidney disease, liver disease, pancreatitis, diabetes, cancer, thyroid disorders and inflammatory diseases, as well as patients with a history of heart attacks and strokes based on patient statements and medical history Pregnancy, lactation and menopause Alcohol consumption, cigarette smoking (at least 5 butts a day for the past 6 months), hookah, other types of tobacco and electronic types (VIP, anti-system)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Leptin gene expression rate (percentage). Timepoint: The beginning and end of the study. Method of measurement: Real-Time Polymerase chain reaction method.;Adiponectin gene expression rate (percentage). Timepoint: The beginning and end of the study. Method of measurement: Real-Time Polymerase chain reaction method.;Leptin serum level. Timepoint: The beginning and end of the study. Method of measurement: Enzyme-linked immunosorbent assay.;Adiponectin serum level. Timepoint: The beginning and end of the study. Method of measurement: Enzyme-linked immunosorbent assay.;Resistin serum level. Timepoint: The beginning and end of the study. Method of measurement: Enzyme-linked immunosorbent assay.;Visfatin serum level. Timepoint: The beginning and end of the study. Method of measurement: Enzyme-linked immunosorbent assay.;MCP-1 serum level. Timepoint: The beginning and end of the study. Method of measurement: Enzyme-linked immunosorbent assay.;Number of headache attacks. Timepoint: The beginning and end of the study. Method of measurement: Questionnaire.;Headache duration. Timepoint: The beginning and end of the study. Method of measurement: Questionnaire.;Headache severity. Timepoint: The beginning and end of the study. Method of measurement: Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sex. Timepoint: The beginning of study. Method of measurement: Questionnaire.;Weight (kg). Timepoint: The beginning and end of study. Method of measurement: scale.;Height (m). Timepoint: The beginning of study. Method of measurement: Height gauge.;Body mass index (kg/m2). Timepoint: The beginning and end of study. Method of measurement: calculation.;Waist circumference (cm). Timepoint: The beginning and end of study. Method of measurement: Meter tape.;Total energy intake (kcal). Timepoint: The three dietary recall 24-hour questionnaires were taken at the beginning and end of the study and twice during the study, including two normal days and one day off (a total of 12 days). Method of measurement: Dietary recall 24-hour questionnaire.;Protein intake (gr). Timepoint: The three dietary recall 24-hour questionnaires were taken at the beginning and end of the study and twice during the study, including two normal days and one day off (a total of 12 days). Method of measurement: Dietary recall 24-hour questionnaire.;Carbohydrate intake (gr). Timepoint: The three dietary recall 24-hour questionnaires were taken at the beginning and end of the study and twice during the study, including two normal days and one day off (a total of 12 days). Method of measurement: Dietary recall 24-hour questionnaire.;Fat intake (gr). Timepoint: The three dietary recall 24-hour questionnaires were taken at the beginning and end of the study and twice during the study, including two normal days and one day off (a total of 12 days). Method of measurement: Dietary recall 24-hour questionnaire.;Cholesterol intake (mg/d). Timepoint: The three dietary recall 24-hour questionnaires were taken at the beginning and end of the study and twice during the study, including two normal days and one day off (a total of 12 days). Method of measurement: Dietary recall 24-hour questionnaire.;Fiber intake (gr/d). Timepoint: The three dietary recall 24-hour questionnaires were taken at the beginning and end of t | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohsen Sedighiyan
Tehran University of Medical Sciences
Outcome results
None listed