alveolar bone deficiency-maxillary sinus pneumatization. Diseases of the musculoskeletal system and connective tissue
Conditions
Interventions
Intervention 1: Intervention group: zenograft + simvastatin solution. Intervention 2: Control group: zenograft alone.
Treatment - Surgery
Intervention group: zenograft + simvastatin solution
Control group: zenograft alone
Sponsors
Vice Chancellor for research of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients who desiring to receive maxillary posterior implants and did not have sufficient bone as determined on cone beam computerized scan (CBCT) for dental implant placement; patients will be partially or completely edentulous in the posterior maxilla, all of them will need bilateral maxillary sinus augmentation surgeries. Exclusion criteria: Patients needing antibiotic prophylaxis for dental procedures; any sinus pathology (acute or chronic) contraindicating the sinus grafting;patients with systemic disease that contraindicating any oral surgeries; patients who smoked more than 10 cigarettes daily; women who were pregnant or wished to become pregnant during the period of the study; patients under 18 years of old; patients with diseases or use of medications known to affect bone metabolism ,tissue regeneration and repair such as corticosteroids, bisphosphonates and etc.; patients with a history of alcoholism or recreational drug abuse; patients who had a history of cancer, radiation to the head and neck in the last 18 months.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Human maxillary sinus bone augmentation by zenograft with or without simvastatin. Timepoint: Preoperatively ,immediately after surgery and at 6 months after sinus graft. Method of measurement: Histomorphometric and radiographic evaluation. | — |
Secondary
| Measure | Time frame |
|---|---|
| New bone formation. Timepoint: At 6 months after sinus graft. Method of measurement: Histomorphometric analysis percent.;Connective tissue. Timepoint: At 6 months after sinus graft. Method of measurement: Histomorphometric analysis percent.;Residual graft material. Timepoint: At 6 months after sinus graft. Method of measurement: Histomorphometric analysis percent.;Bone height analysis. Timepoint: Preoperatively ,immediately after surgery and at 6 months after sinus graft. Method of measurement: CBCT analysis.;Bone density analysis. Timepoint: 6 months after sinus graft. Method of measurement: CBCT analysis. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactChokami Rafiei Sahar
Peridontology Department, Dental Faculty of Tehran University of Medical Sciences
Outcome results
None listed