erosion (acute) of stomach. Gastric ulcer
Conditions
Interventions
patients for prophylaxis treated with omeprazol suspension (40mg)every day via nasogastric tube for 14 days. Gastric aspirates were sampled before(empty stomach) and 1.5-2 hours after administration o
Treatment - Drugs
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 95 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age of =16 yrs of age; anticipated stay of =72 hrs in ICU; required mechanical ventilation more than 48 hrs; APACHE II score =11; have a nasogastric or orogastric tube in place; have at least one additional risk factor for upper GI bleeding Exclusion criteria: status of no CPR; delay of >48 hrs from time of initial eligibility; history of gastric surgery; allergy to omeprazole; active GI bleeding; significant risk of swallowing blood; admission for upper GI surgery; known upper GI Lesions that might bleed; inability to take a suspension by nasogastric tube;end-stage liver disease
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean gastric pH. Timepoint: before and 1-2.5 hrs after drug administration. Method of measurement: pH meter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Active upper GI bleeding. Timepoint: every day up to 14 days. Method of measurement: Gastroccult test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDoctor Fanak Fahimi
Shahid Beheshti University of Medical Sceinces,Faculty of pharmacy
Outcome results
None listed