Efficacy of Dexmedetomidine infusion on the bleeding in endoscopic sinus surgery.

Efficacy of Dexmedetomidine infusion on the bleeding and quality of surgical field in patients who undergo endoscopic sinus surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201606211138N23

Enrollment

Registered

2016-08-13

Start date

2016-08-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic sinusitis. Chronic sinusitis

Interventions

Intervention 1: First group: Dexmedetomidine 1/mg /kg in 10 mL of saline 9/0% during the 10 minutes before induction of anesthesia and then infusion continues at a dose of 0.2 to 1/mg/kg/hr. Intervent

Prevention

First group: Dexmedetomidine 1/mg /kg in 10 mL of saline 9/0% during the 10 minutes before induction of anesthesia and then infusion continues at a dose of 0.2 to 1/mg/kg/hr.

second group: receive only anesthesia similar to the first group without infusion of Dexmedetomidine.

Eligibility

Sex/Gender

All

Age

16 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients aged between 16-60 years who undergo endoscopic sinus surgery; those with hemoglobin more than 10 mg/dL; normal clotting time and bleeding time; normal PT; PTT; INR; no history of airways problems and systemic disease or Mental disorders; no history of the anesthetic drugs sensitivity or any other medication and no history of bleeding disorders (such as hemophilia) ;Exclusion criteria: Use of anticoagulants such as heparin 48 hours before surgery; history of acute and chronic renal failure; diabetes; stroke; coronary artery disease; hypertension; deep vein thrombosis; pulmonary embolism; peripheral vascular diseases; pregnancy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The amount of bleeding during surgery. Timepoint: in time intervals between 15; 30; 60 and 90 minutes. Method of measurement: scale Boezaart.	—

Secondary

Measure	Time frame
Systolic and diastolic blood pressure and Mean Arterial Pressure. Timepoint: in time intervals between 15; 30; 60 and 90 minutes. Method of measurement: Mercury manometers.;Heart rate. Timepoint: in time intervals between 15; 30; 60 and 90 minutes. Method of measurement: Electrocardiogram.;Surgeon satisfaction. Timepoint: in time intervals between 15; 30; 60 and 90 minutes. Method of measurement: Likert scale.;Duration of surgery. Timepoint: in time intervals between 15; 30; 60 and 90 minutes. Method of measurement: clock.	—

Measure

Time frame

Systolic and diastolic blood pressure and Mean Arterial Pressure. Timepoint: in time intervals between 15; 30; 60 and 90 minutes. Method of measurement: Mercury manometers.;Heart rate. Timepoint: in time intervals between 15; 30; 60 and 90 minutes. Method of measurement: Electrocardiogram.;Surgeon satisfaction. Timepoint: in time intervals between 15; 30; 60 and 90 minutes. Method of measurement: Likert scale.;Duration of surgery. Timepoint: in time intervals between 15; 30; 60 and 90 minutes. Method of measurement: clock.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Soudabeh Haddadi

Guilan University of Medical Sciences

So_haddadi@yahoo.com+98 13 3322 5242

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026