The effect of photodynamic therapy on oral lichen planus

Comparision the effect of topical corticosteroid with photodynamic therapy and topical corticosteroid on pain and size of lesions in oral lichen planus patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201606208585N2

Enrollment

Registered

2017-08-02

Start date

2016-09-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oral lichen planus. Lichen planus

Interventions

Intervention 1: In intervention side (one side of the patients’ mouth), photodynamic therapy will be applied for erosive/ulcerative lesions on day 1, 3, 5. Topical toluidine will be applied blue with

Treatment - Other

Treatment - Drugs

In intervention side (one side of the patients’ mouth), photodynamic therapy will be applied for erosive/ulcerative lesions on day 1, 3, 5. Topical toluidine will be applied blue with micropipette for

In control side (other side of the mouth), topical toluidine blue with micropipette and sham laser irradiation will be on day 1, 3 and 5. After two weeks, topical triamcinolone [triamcinolone acetonid

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: Histopathologically and clinically confirmed oral lichen planus Bilateral atrophic or erosive or ulcerative oral lichen planus Signing informed consent Exclusion criteria: The patients under 18 years old Positive history of other inflammatory diseases, malignancies or even dysplastic lesions The patients who have received treatment for oral lichen planus lesions since a previous month Pregnant women The patients with history of photo sensitivity

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: day1, 3, 5, week 3, 5, 7. Method of measurement: VAS.;Size. Timepoint: day1, 3, 5, week 3, 5, 7. Method of measurement: scaled tongue blade(mm).;Clinical presentation or inflammation. Timepoint: day1, 3, 5, week 3, 5, 7. Method of measurement: Thongprasom sign scoring.	—

Secondary

Measure	Time frame
Toluidine blue hypersensivity. Timepoint: day1, 3, 5. Method of measurement: clinical symptom of hypersensitivity.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Lavaee

Oral and Maxillofacial Medicine Department, School of Dentistry, Shiraz University of Medical Scienc

lavaeef@sums.ac.ir+98 71 3631 9309

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026