Comparing effect of the spinal anesthesia induced hypotension treatments on neonatal factors

Comparison of the treatment of spinal anesthesia induced hypotension by Ephedrine or Phenylephrine on the Neonatal Arterial Blood Gas and Apgar score in Cesarean Delivery of Obese Parturient

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016062028545N1

Enrollment

120

Registered

2016-09-10

Start date

2016-09-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Other complications of spinal and epidural anaesthesia during labour and delivery. Other complications of spinal and epidural anaesthesia during labour and delivery

Interventions

Intervention 1: Ephedrine administration: injection of 5-10 milligram intravenous ephedrine up to 20 milligram, as vasopressor in case of hypotension. Intervention 2: Phenylephrine: injection of 50 mi

Treatment - Drugs

Ephedrine administration: injection of 5-10 milligram intravenous ephedrine up to 20 milligram, as vasopressor in case of hypotension.

Phenylephrine: injection of 50 micrograms intravenous ephedrine up to 200 microgram, as vasopressor in case of hypotension.

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: interest to participate in study; obesity (BMI30 kg/m2); no underlying diseases except obesity; Class II category in ASA grading system; age between 18-40; term pregnancy; singleton pregnancy; candidate for elective cesarean section; candidate for epidural anesthesia. Exclusion criteria: emergency cesarean section; diabetic mother; no consent to participate in study; gestational hypertension; epidural anesthesia contraindications; twin pregnancy; need to change epidural anesthesia to general anesthesia; intraoperative bleeding more than 1000 milliliter; neonate birth body weight less than 2500 grams.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Umbilical artery blood pH. Timepoint: Right after neonate birth. Method of measurement: Arterial blood gas test.;Umbilical artery blood pO2. Timepoint: Right after neonate birth. Method of measurement: Arterial blood gas test.;Umbilical artery blood pCO2. Timepoint: Right after neonate birth. Method of measurement: Arterial blood gas test.	—

Secondary

Measure	Time frame
APGAR. Timepoint: APGAR in the first minute after delivery. Method of measurement: APGAR scoring system.;APGAR. Timepoint: APGAR in the fifth minute after delivery. Method of measurement: APGAR scoring system.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHassan Soleiman Pour

Medicine faculty

soleimanpourh@tbzmed.ac.ir+98 41 3441 3895

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026