The effect of preconditioning of sevofluran in cardiac ischemia

The effect of preconditioning of sevofluran in coronary artery bypass surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016061528477N1

Enrollment

Registered

2016-08-02

Start date

2015-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preconditioning of heart during coronary artery bypass surgery. Unspecified complication of cardiac and vascular prosthetic device, implant and graft

Interventions

Intervention 1: Intervention: after induction of anesthesia in intervention group, the patient will receive oxygen (2Lit/min) and sevofluran(4%) during coronary bypass surgery. Intervention 2: Contro

Treatment - Drugs

Intervention: after induction of anesthesia in intervention group, the patient will receive oxygen (2Lit/min) and sevofluran(4%) during coronary bypass surgery.

Control: after induction of anesthesia in control group, the patient will receive oxygen(2Lit/min).

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: All elective coronary bypass surgery in patients 40 to 80 years old. Exclusion criteria: AV block(mobitz2); complete Heart block; LBBB; Acute heart failure(EF<30); Reexploration after surgical complications ; MI in last 7 days ago.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Troponin I blood level. Timepoint: At entrance to ICU and after 4,8,24,48 hours from coronary bypass surgery. Method of measurement: µg / l0.01 SI unit.;Electrocardiography. Timepoint: ECG changes at entrance to ICU and daily up to 4 days. Method of measurement: Electrocardiography device.;Nuclear heart scan. Timepoint: 3 nuclear heart scan befor CABG and 1 and 6 month after surgery. Method of measurement: SPECT-CT Scan.	—

Measure

Time frame

Troponin I blood level. Timepoint: At entrance to ICU and after 4,8,24,48 hours from coronary bypass surgery. Method of measurement: µg / l0.01 SI unit.;Electrocardiography. Timepoint: ECG changes at entrance to ICU and daily up to 4 days. Method of measurement: Electrocardiography device.;Nuclear heart scan. Timepoint: 3 nuclear heart scan befor CABG and 1 and 6 month after surgery. Method of measurement: SPECT-CT Scan.

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Secondary

Measure	Time frame
Systolic blood pressure. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.;Diastolic blood pressure. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.;Mean arterial pressure. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.;Heart rate. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.;Diastolic blood pressure. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.;Mean arterial pressure. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.;Heart rate. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Anvaripour

Boushehr Medical Scinces University

sina_rezaei_70@yahoo.com+98 77 3345 0178

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026