Non-erosive gastroesophageal reflux disease (NERD). Gastroesophageal reflux disease without esophagitis
Conditions
Interventions
Control group: placebo tablet (two 500 mg tablets, two times a day for 4 weeks, after lunch and dinner)
Intervention 1: Intervention group:Phyllanthus amblica tablet (two 500 mg tablets, two times a day for 4 weeks, after lunch and dinner). Intervention 2: Control group: placebo tablet (two 500 mg tabl
Treatment - Drugs
Intervention group:Phyllanthus amblica tablet (two 500 mg tablets, two times a day for 4 weeks, after lunch and dinner)
Sponsors
Vice chancellor for research,School of Traditional Medicine, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 83 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: having the classic symptoms of reflux disease and normal endoscopy; patients with 16 to 80 years old; the normal examination by a gastroenterologist Exclusion criteria: erosive esophagitis in endoscopy; smoking; ongoing alcohol users; OB positive; risk of peptic ulcer or cancer; pregnant women; breast feeding women; any digestive disorder which requires new protocols; significant surgical or medical disorders clinically; hospitalization; use of PPI for 10 days ago; and use of H2 blocker for 2 weeks ago.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain or heartburn. Timepoint: At the begining, end of the Second week, end of the forth week. Method of measurement: Gastroesophageal reflux standard questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Acid regurgitasion /sour taste in the mouth. Timepoint: At the begining, end of the Second week, end of the forth week. Method of measurement: Gastroesophageal reflux standard questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahnaz Karkon Varnosfaderani
School of Traditional Medicine, Tehran University of Medical Sciences (TUMS)
Outcome results
None listed