Delirium. Postoperative Delirium
Conditions
Interventions
Intervention 1: The intervention group: 14 Memantin tablets 10 miligram for the twice-daily use for a week from three days before surgery to three days then. Intervention 2: Control group:14 tablets
Treatment - Drugs
The intervention group: 14 Memantin tablets 10 miligram for the twice-daily use for a week from three days before surgery to three days then
Control group:14 tablets of Memantine placebo for the twice-daily use for a week from three days before surgery to three days then
Sponsors
Vice chancellor for research Yazd Shahid Sadoughi University of medical sciences
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients aged 50 to 70 years, Signing the informed consent form. Exclusion criteria: EF (ejection fraction) of less than 35%, alcohol and drug abuse, pregnancy and lactation, brain damage, kidney failure (creatinine greater than 1.4), liver failure, scores of MMSE (Mini-Mental State Examination) less than 22? concurrent use of Cholinesterase inhibitors.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delirium. Timepoint: 3 days after operation. Method of measurement: Questionnaire of CAM-ICU. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug side effects. Timepoint: 3 days after operation. Method of measurement: Examination and test results. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir Houshang Mehrparvar
Yazd Shahid Sadoughi university of medical sciences
Outcome results
None listed