DIABETES. Non-insulin-dependent diabetes mellitus without complications
Conditions
Interventions
Intervention 1: The intervention group: capsules 1 gr Cinnamon, 3 times per day, for 8 weeks. Intervention 2: Control group: capsules 1 gr microcristalin cellulose, 3 times per day, for 8 weeks.
Treatment - Drugs
The intervention group: capsules 1 gr Cinnamon, 3 times per day, for 8 weeks.
Control group: capsules 1 gr microcristalin cellulose, 3 times per day, for 8 weeks.
Sponsors
National Nutrition & Food Technology Research Institute (NNFTRI)
Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
70 Years to 25 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria : Having type 2 diabetes for at least 10 years? FBS <180 and 2 h-blood-sugar <250 mg/dl? no pregnancy or lactation? no autoimmune disorder? without any thyroid , kidney , CVD diseases, thyroid and chronic inflammatory diseases, peptic ulcer and infection? no regular consumption of cinnamon or other herbal drugs? no sensitivity People who are just using the pills (not insulin)? your diabetes control cinnamon? body mass index (BMI) <30 kg/m ? Age between 70-25 years. Exclusion criteria : No observation of research protocol (no consumption of more than 20% of the capsules)? any sensitivity due to cinnamon consumption reported by the patient or noticed after the outset of the study? consumption of alcohol or narcotic drugs? and any variation in patients’ routine treatment according to physicians’ resolution (i.e., variation in type and dose of the drugs to be consumed, and treatment with insulin)? Pregnancy during the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sirtuin Activity 1. Timepoint: Before and after the intervention. Method of measurement: ng/ml.;Fasting insulin. Timepoint: Before and after the intervention. Method of measurement: mU/L.;HOMA-IR. Timepoint: Before and after the intervention. Method of measurement: %.;Fasting plasma glucose. Timepoint: Before and after the intervention. Method of measurement: mg/dl.;Carboxymethyl-lysine plasma. Timepoint: Before and after the intervention. Method of measurement: ng/ml.;Hb A1c. Timepoint: Before and after the intervention. Method of measurement: %.;The activity NF-kB. Timepoint: Before and after the intervention. Method of measurement: ng/ml.;VCAM-1. Timepoint: Before and after the intervention. Method of measurement: ng/ml.;Hs-CRP. Timepoint: Before and after the intervention. Method of measurement: ng/ml.;IL-6. Timepoint: Before and after the intervention. Method of measurement: ng/L.;TNF. Timepoint: Before and after the intervention. Method of measurement: ng/L.;ICAM-1. Timepoint: Before and after the intervention. Method of measurement: ng/ml. | — |
Secondary
| Measure | Time frame |
|---|---|
| Vitamin E diet. Timepoint: Before and after the intervention. Method of measurement: mg/day.;MUFA. Timepoint: Before and after the intervention. Method of measurement: gr/day.;PUFA. Timepoint: Before and after the intervention. Method of measurement: gr/day.;Salt diet. Timepoint: Before and after the intervention. Method of measurement: gr/day.;SAFA. Timepoint: Before and after the intervention. Method of measurement: gr/day.;Fat Diet. Timepoint: Before and after the intervention. Method of measurement: gr/day.;Cholesterol diet. Timepoint: Before and after the intervention. Method of measurement: mg/day.;Dietary fiber. Timepoint: Before and after the intervention. Method of measurement: mg/day.;Protein Diet. Timepoint: Before and after the intervention. Method of measurement: gr/day.;BMI. Timepoint: Before and after the intervention. Method of measurement: Kilograms per square meter.;Carb Diet. Timepoint: Before and after the intervention. Method of measurement: gr/day.;Total dietary energy. Timepoint: Before and after the intervention. Method of measurement: Kcal/day.;Vitamin C diet. Timepoint: Before and after the intervention. Method of measurement: mg/day.;Selenium diet. Timepoint: Before and after the intervention. Method of measurement: mcg/day. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehrouz Talaei
Shahid Beheshti University of Medical Sciences Faculty of Nutrition Sciences and food technology
Outcome results
None listed