Headache caused by drug abuse. Drug-induced headache
Conditions
Interventions
Intervention 1: Prednisolone 50mg/1kg for 5 days. Additionally, a random group will receive Nortriptyline 10mg every 24 hours. Intervention 2: Prednisolone 50mg/1kg for 5 days. Additionally, a random
Treatment - Drugs
Prednisolone 50mg/1kg for 5 days. Additionally, a random group will receive Nortriptyline 10mg every 24 hours
Prednisolone 50mg/1kg for 5 days. Additionally, a random group will receive Sodium Valproate 200mg every 12 hours for 2 month
Sponsors
Vice Chancellor for Research of Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age between 15-60 years; daily headache present on 15day/month; regular overuse for >3 month of 1 or more acute/symptomatic treatment drugs; headache has developed during medication overuse. Exclusion criteria: Age<15 years, severe systemic pathologic associated to chronic headache; major psychiatric disorder such as major depression; hypochondriasis; Contraindication or sensitivity to drugs use in study; pregnancy or lactation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of headache attack s. Timepoint: Before treatment, after 2 month of treatment. Method of measurement: number.;Remission headache. Timepoint: Before treatment, after 2 month of treatment. Method of measurement: Qualitative and based on the positive or negative.;The days of headache. Timepoint: Before treatment, after 2 month of treatment. Method of measurement: day. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug side effect. Timepoint: At the start of the intervention, after 2 month of treatment. Method of measurement: questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Akbar Moghadamnia
Babol University of Medical Sciences
Outcome results
None listed