FindTrial
Sign In

The effect of Naltrexone on memory deficit induced by Electroconvulsive therapy

Comparison of the effects of Naltrexone versus placebo on memory deficit followed by Electroconvulsive therapy in depressed patients: A double blind clinical trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016060628309N1
Enrollment
40
Registered
2016-09-02
Start date
2012-03-19
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Depressive Episode. Condition 2: Memory deficit induced by electroconvulsive therapy. Depressive episode

Interventions

Intervention 1: Intervention Group: Naltrexone cap 50 mg , The night before ECT session. Intervention 2: Control Group: Placebo Capsule The afternoon before ECT session.
Treatment - Drugs
Placebo
Intervention Group: Naltrexone cap 50 mg , The night before ECT session
Control Group: Placebo Capsule The afternoon before ECT session

Sponsors

Vice chancellor for research,Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria : aged 18 to 65 years; major depression or bipolar depression disorder patients based on DSM4 criteria; indicated for ECT Exclusion criteria: affected by a prominent medical condition; diagnosed with schizophrenia or mania; a history of ECT in the last 6 month; recent opioid use

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Memory deficit. Timepoint: At the day before ECT sessions, two weeks, one month and three months after ECT sessions. Method of measurement: Wechsler memory test.—

Secondary

MeasureTime frame
Depression severity. Timepoint: Before and 3 months after ECT session. Method of measurement: Hamilton Depression Questionair.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSomayeh Motazedian

Fasa university of medical sciences

somayehmotazedian@yahoo.com+98 71 5331 4234

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026