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Efficacy of Solifenacin and trospium chloride on neurogenic bladder

Efficacy of Solifenacin and trospium chloride on neurogenic bladder after stroke: a multicentric three arms placebo-controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160606028304N2
Enrollment
201
Registered
2020-06-06
Start date
2021-07-01
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: stroke. Condition 2: neurogenic bladder. Cerebrovascular disease, unspecified Neuromuscular dysfunction of bladder, unspecified

Interventions

Intervention 1: Intervention group 1, antimuscarinic drug approved in OAB treatment, Solifenacin: this group of patients will be treated with oral solifenacin 10mg tablet daily for 30 days. In this wa

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Stroke diagnosis patients Normal cognitive function Lower urinary tract symptomes Patients with CVA should be ambulatory, able to communicate, and record a voiding diary age =18 years

Exclusion criteria

Exclusion criteria: Evidence of brain stem or bilateral signs on examination Mental disorders according to the patient's own statement Having history of LUTS surgery, pelvic and urologic surgery, or trauma Other severe neurological disease including dementia Severe psychiatric disease Prostate cancer Patients who refuse consent Abnormal liver function severe constipation patiensts with previous history of hypersensitivity reaction to anticholinergics or closed anterior chamber glaucoma

Design outcomes

Primary

MeasureTime frame
NBSS score. Timepoint: begining of study and 4 weeks after intervention. Method of measurement: questionnaire.;ICIQ-UI score. Timepoint: begining of study and 4 weeks after intervention. Method of measurement: questionnaire.;I-QOL test score. Timepoint: begining of study and 4 weeks after intervention. Method of measurement: questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Pormohammad

Tabriz University of Medical Sciences

alirmd@outlook.com+98 41 3381 4472

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 5, 2026