The effect of choline supplement on autonomic system

The effects of acute and short-term supplementation of choline on responses of the autonomic and hemodynamic system to sprint interval exercise in overweight and obese individuals

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160606028290N2

Enrollment

Registered

2022-02-15

Start date

2022-04-09

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The cardiac autonomic system of overweight or obese women with body mass index (BMI) 27<, and their age be between 20 to 40.. Overweight and obesity

Interventions

Intervention 1: The intervention group will consume Alpha-GPC Choline supplement in acute (single dose) and chronic (seven days) phases. Participants will consume Alpha-GPC Choline (1000 mg) which wil

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: body mass index (BMI) > 27 no regular exercise/physical activity in the last year according to the recommendation of the American College of Sport Medicine for exercise (150 min moderate-intensity exercise or 75 min vigorous exercise per week) nonsmoker no alcohol consumption in the last two month no experiences or diagnosed illness (Hypertension, diabetes, etc.), especially cardiovascular diseases

Exclusion criteria

Exclusion criteria: If they used high choline diets (According to 48 hours food frequency questioner) dietary supplements, or medication that could affect the study's cardiac autonomic function and hemodynamics variables

Design outcomes

Primary

Measure	Time frame
Heart rate variability (HRV): Changes in heart rate signals in the time interval between two consecutive heartbeats that are recorded using a heart rate Holter device and represent the quality of the cardiac autonomic system and the time-based method (domain time) frequency-based (frequency domain) is used to measure it. The main HRV variables in the current study will be included: Standard Deviation of RR wave intervals (SDNN), high frequency (HF), low frequency (LF), the ratio of LF to HF (LF/HF) bands, and percentage of interval differences of adjacent RR intervals greater than 50 ms (pNN50). Timepoint: In the acute phase, the HRV variables will be measured before using choline supplement or placebo, 60 min after consuming choline supplement or placebo, immediately after the exercise test, 120 min following it (every 15 min). In the chronic phase, the HRV variables will be measured before starting consuming choline or placebo for seven days, after seven days, before using the last dose of choline or placebo on the seventh day, 60 min after consuming choline or placebo, immediately after the exercise test, 120 min following it (every 15 min). Method of measurement: myPatch®sl Holter monitor (dms-service, made in USA).;Hemodynamic variables which in the current study will be included: systolic blood pressure and diastolic blood pressure. Timepoint: In the acute phase, the hemodynamic variables will be measured before using choline supplement or placebo, 60 min after consuming choline supplement or placebo, immediately after the exercise test, 120 min following it (every 15 min). In the chronic phase, the hemodynamic variables will be measured before starting consuming choline or placebo for seven days, after seven days, before using the last dose of choline or placebo on the seventh day, 60 min after consuming choline or placebo, immediately after the exercise test, 120 min following it (every 15 min). Method of measurement: Automatic Arm Blood Pressure Monitor JPN	—

Measure

Time frame

Heart rate variability (HRV): Changes in heart rate signals in the time interval between two consecutive heartbeats that are recorded using a heart rate Holter device and represent the quality of the cardiac autonomic system and the time-based method (domain time) frequency-based (frequency domain) is used to measure it. The main HRV variables in the current study will be included: Standard Deviation of RR wave intervals (SDNN), high frequency (HF), low frequency (LF), the ratio of LF to HF (LF/HF) bands, and percentage of interval differences of adjacent RR intervals greater than 50 ms (pNN50). Timepoint: In the acute phase, the HRV variables will be measured before using choline supplement or placebo, 60 min after consuming choline supplement or placebo, immediately after the exercise test, 120 min following it (every 15 min). In the chronic phase, the HRV variables will be measured before starting consuming choline or placebo for seven days, after seven days, before using the last dose of choline or placebo on the seventh day, 60 min after consuming choline or placebo, immediately after the exercise test, 120 min following it (every 15 min). Method of measurement: myPatch®sl Holter monitor (dms-service, made in USA).;Hemodynamic variables which in the current study will be included: systolic blood pressure and diastolic blood pressure. Timepoint: In the acute phase, the hemodynamic variables will be measured before using choline supplement or placebo, 60 min after consuming choline supplement or placebo, immediately after the exercise test, 120 min following it (every 15 min). In the chronic phase, the hemodynamic variables will be measured before starting consuming choline or placebo for seven days, after seven days, before using the last dose of choline or placebo on the seventh day, 60 min after consuming choline or placebo, immediately after the exercise test, 120 min following it (every 15 min). Method of measurement: Automatic Arm Blood Pressure Monitor JPN

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSajad Ahmadizad

Shahid Beheshti University

s_ahmadizad@sbu.ac.ir+98 21 2990 5821

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026