Skip to content

Comparison of the effects of ketamine, magnesium sulfate and nesdonal on propofol injection pain

Comparison of the effects of ketamine, Magnesium sulfate and Nesdonal on Propofol injection pain in patients undergoing elective surgery

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016060528283N1
Enrollment
75
Registered
2016-07-19
Start date
2013-01-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain. Other and unspecified general anaesthetics

Interventions

Intervention 1: An 18-gauge intravenous catheter will be inserted for all patients in the dorsum of the hand. One minute prior to Propofol injection, all patients will be received the study drug throu
production series 11-207). Next, 2.5 mg/kg of Propofol 2% (Melsugen, Germany
production series- 34209) will be administered at a rate of i 1 ml/s. Verbal Rating Scale (VRS) will be used to assess the severity of pain during injection. Intervention 2: An 18-gauge intravenous ca
production series 1228054891). Next, 2.5 mg/kg of Propofol 2% (Melsugen, Germany
production series- 34209) will be administered at a rate of i 1 ml/s. Verbal Rating Scale (VRS) will be used to assess the severity of pain during injection. Intervention 3: An 18-gauge intravenous ca
production series -207) at a rate of 1 mg/s. Next, 2.5 mg/kg of Propofol 2% (Melsugen, Germany
production series- 34209) will be administered at a rate of i 1 ml/s. Verbal Rating Scale (VRS) will be used to assess the severity of pain during injection.
Treatment - Drugs
An 18-gauge intravenous catheter will be inserted for all patients in the dorsum of the hand. One minute prior to Propofol injection, all patients will be received the study drug through a 5 ml syring
production series- 34209) will be administered at a rate of i 1 ml/s. Verbal Rating Scale (VRS) will be used to assess the severity of pain during injection

Sponsors

Vice Chancellor for research Mazandaran University of Medical Sciences.
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria ; class I and II ASA Exclusion criteria; patients with high intracranial pressure, unstable hemodynamics, severe mental disorders, history of allergy to drugs used, kidney, liver or heart dysfunction, addiction and use of Calcium or Magnesium blockers

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Propofol injection pain. Timepoint: Once. Method of measurement: Verbal Rating Scale.

Secondary

MeasureTime frame
Side effects. Timepoint: For 1 hours. Method of measurement: Surveillance the patients.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAttieh Nikkhah

Mazandaran University of Medical Sciences

atinik1357@gmail.com+98 11 3326 8923

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026