Bronchodilator Effect of Nebulized Hypertonic 3% Saline in Asthma Attack

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016060526630N2

Enrollment

337

Registered

2016-06-21

Start date

2014-05-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Exacerbation of Asthma. Asthma

Interventions

Intervention 1: Intervention Group: Salbutamol 2.5mg each 20 minutes via nebulizer Atrovent 2.5mg each 20 minutes via nebulizer Prednisolone 50mg one time by mouth MgSO4 2gr one time IV infusion in 20

Treatment - Drugs

Intervention Group: Salbutamol 2.5mg each 20 minutes via nebulizer Atrovent 2.5mg each 20 minutes via nebulizer Prednisolone 50mg one time by mouth MgSO4 2gr one time IV infusion in 20 minutes, 3% Sal

Control Group: Salbutamol 2.5mg each 20 minutes with nebulizer Atrovent 2.5mg each 20 minutes with nebulizer Prednisolone 50mg by mouth one time MgSO4 2g intravenous infusion in 20 minutes

Eligibility

Sex/Gender

All

Age

15 Years to 139 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Acute Asthma Attack with: Age above 15 years old; Clinically or Para-clinically Asthma History Exclusion Criteria: History of Cardiovascular Diseases; History of COPD; History of other pulmonary diseases; History of Smoking more than 10 years; Pregnant women; Systolic Blood Pressure less than 100 mmHg

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Forced Expiratory Volume in First Second (FEV1). Timepoint: Before intervention, 20 minutes after intervention, 40 minutes after intervention, 60 minutes after intervention. Method of measurement: Milliliter with use of Peak Flow Meter.;Peak Expiratory Flow Rate (PEFR). Timepoint: Before intervention, 20 minutes after intervention, 40 minutes after intervention, 60 minutes after intervention. Method of measurement: Milliliter with use of Peak Flow Meter.	—

Measure

Time frame

Forced Expiratory Volume in First Second (FEV1). Timepoint: Before intervention, 20 minutes after intervention, 40 minutes after intervention, 60 minutes after intervention. Method of measurement: Milliliter with use of Peak Flow Meter.;Peak Expiratory Flow Rate (PEFR). Timepoint: Before intervention, 20 minutes after intervention, 40 minutes after intervention, 60 minutes after intervention. Method of measurement: Milliliter with use of Peak Flow Meter.

—

Secondary

Measure	Time frame
Blood Pressure. Timepoint: Before Intervention. Method of measurement: Millimeter of Hg.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Arash Forouzan

Ahvaz Jundishapur University of Medical Sciences

arash-forouzan@ajums.ac.ir+98 61 3374 3079

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026