acute myocardial infarction. Acute transmural myocardial infarction of unspecified site
Conditions
Interventions
Intervention 1: Interventional group: moreover the routin treatment, before primary PCI and stenting of culprit lesion 3 gram of intravenus vitamin C bolusand after stenting 96 mg again will be in
Treatment - Drugs
Control group: routine treatement
Interventional group: moreover the routin treatment, before primary PCI and stenting of culprit lesion 3 gram of intravenus vitamin C bolusand after stenting 96 mg again will be inject.
Sponsors
Vice chancellor for research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: Subjects (men or women) at least 18 years and less than 80 years of age; Ischemic discomfort =20 minutes and =6 hours of duration; ST elevation =1mm (=0.1mV) in two contiguous limb leads OR =2mm (=0.2mV) in two contiguous precordial leads; Planned primary PCI within 2 hours of hospital presentation; Planned or concomitant use of aspirin, clopidogrel, unfractionated heparin, and Glycoprotein IIb/IIIa inhibition with intent to stent the infarct-related artery; Informed consent able to be obtaine Exclusion Criteria: Age =80 years; Cardiac arrest or arrhythmia requiring chest compressions or cardiopulmonary resuscitation; Current warfarin therapy; Known allergy or contraindication to fibrinolytics OR aspirin OR heparin OR clopidogrel; Patients with evidence of coronary collaterals (2-3 Rentrop) to the region at risk on previous coronary angiography (at the previous admission) .
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial infarction. Timepoint: before intervention. Method of measurement: clinical history and ECG.;Myocardial perfusion grade. Timepoint: after PCI. Method of measurement: by angiographic interpretation.;TIMI flow. Timepoint: after stenting. Method of measurement: by angiographic interpretation.;P selectin kit. Timepoint: one month. Method of measurement: ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHaj HoseinTalasaz Azita
Tehran University of Medical Sciences
Outcome results
None listed