Effect of curcumin supplement in patients with beta thalassemia major

Effect of curcumin supplementation on iron overload, oxidative stress and insulin resistance in patients with beta thalassemia major

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016053028165N1

Enrollment

Registered

2016-06-30

Start date

2015-09-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Beta thalassemia major. Beta thalassaemia

Interventions

Intervention 1: Intervention group will take 2 curcumin capsules per day (each containing 500 mg curcuminoids) for 12 weeks. Intervention 2: Control group will take 2 placebo capsules daily for 12 we

Treatment - Drugs

Placebo

Intervention group will take 2 curcumin capsules per day (each containing 500 mg curcuminoids) for 12 weeks

Control group will take 2 placebo capsules daily for 12 weeks. Placebo capsules are similar in size and color to the curcumin capsules

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age between 18 and 40, Regular blood transfusions based on prescription, consumption of deferoxamine as an iron chelator drug, Not taking any nutritional supplements from 3 months before the start of the study, patients without hepatitis B, C, HIV and chronic kidney and heart diseases, not using other chelator medication except deferoxamine. Excluson criteria: A significant change in dose of deferoxamine therapy during the study, using another iron chelator drug in addition to deferoxamine and pregnancy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hemoglobin. Timepoint: Before the study and after the study. Method of measurement: Cyanmethemoglobin method.;Serum iron. Timepoint: Before the study and after the study. Method of measurement: Spectrophotometry.;Ferritin. Timepoint: Before the study and after the study. Method of measurement: Elisa.;Hepcidin. Timepoint: Before the study and after the study. Method of measurement: Elisa.;Non-transferrin-bound iron. Timepoint: Before the study and after the study. Method of measurement: HPLC.;Malondialdehyde. Timepoint: Before the study and after the study. Method of measurement: Spectrophotometry.;Serum total antioxidant capacity. Timepoint: Before the study and after the study. Method of measurement: FRAP.;Catalase. Timepoint: Before the study and after the study. Method of measurement: Spectrophotometry.;Glucose. Timepoint: Before the study and after the study. Method of measurement: Enzymatic method.;Insulin. Timepoint: Before the study and after the study. Method of measurement: Elisa.;Insulin resistance. Timepoint: Before the study and after the study. Method of measurement: Calculation by using formula.	—

Measure

Time frame

Hemoglobin. Timepoint: Before the study and after the study. Method of measurement: Cyanmethemoglobin method.;Serum iron. Timepoint: Before the study and after the study. Method of measurement: Spectrophotometry.;Ferritin. Timepoint: Before the study and after the study. Method of measurement: Elisa.;Hepcidin. Timepoint: Before the study and after the study. Method of measurement: Elisa.;Non-transferrin-bound iron. Timepoint: Before the study and after the study. Method of measurement: HPLC.;Malondialdehyde. Timepoint: Before the study and after the study. Method of measurement: Spectrophotometry.;Serum total antioxidant capacity. Timepoint: Before the study and after the study. Method of measurement: FRAP.;Catalase. Timepoint: Before the study and after the study. Method of measurement: Spectrophotometry.;Glucose. Timepoint: Before the study and after the study. Method of measurement: Enzymatic method.;Insulin. Timepoint: Before the study and after the study. Method of measurement: Elisa.;Insulin resistance. Timepoint: Before the study and after the study. Method of measurement: Calculation by using formula.

—

Secondary

Measure	Time frame
Weight. Timepoint: before the study and after the study. Method of measurement: Scale.;Body mass index (BMI). Timepoint: Before the study and after the study. Method of measurement: Calculation by using formula.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElahe Mohammadi

National Nutrition and Food Technology Research Institute

E.mohamadi52@yahoo.com+98 21 2235 7486

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026