Comparison of the effect of Norepinephrin and Ephedrine in the treatment of hypotension due to spinal anesthesia in cesarean section on fetal umbilical cord PH

Comparison of the effect of Norepinephrin and Ephedrine in the treatment of hypotension due to spinal anesthesia in cesarean section on fetal umbilical cord pH - A double-blinded randomized controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160529028141N4

Enrollment

Registered

2022-10-29

Start date

2022-10-23

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension induced by spinal anesthesia in cesarean section. Other complications of spinal and epidural anesthesia during labor and delivery

Interventions

Intervention 1: Intervention: In case of hypotension induced by spinal anesthesia (drop in systolic blood pressure more than 20% of baseline), 10 milligram bolus norepinephrine will be injected. Inte

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Pregnant women Age 20 to 35 years Candidate for elective cesarean section Singleton pregnancy Gestational age 36 to 40 weeks

Exclusion criteria

Exclusion criteria: History of hypertension (>140/90) History of cardiovascular or cerebrovascular diseases Gestational hypertension History of high-risk pregnancies (e.g. multiparity or intrauterine growth retardation) Abnormalities of the placenta and umbilical cord Contraindications to spinal anesthesia (patient refusal for spinal anesthesia, coagulopathies, infection in the anesthesia area, bleeding or hypovolemic shock)

Design outcomes

Primary

Measure	Time frame
Umbilical artery pH level. Timepoint: Immediately after delivery. Method of measurement: Biochemical tests.;Umbilical artery lactate level. Timepoint: Immediately after delivery. Method of measurement: Biochemical tests.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Mazouri

Iran University of Medical Sciences

mazouri.a@iums.ac.ir+98 21 2293 9996

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026