Asthma. Mixed asthma
Conditions
Interventions
Intervention 1: Patients in intervention will receive 2 mcg/kg/min intravenous Alprostadil and Albuterol with 20 minutes interval in three dosages via inhalation. Intervention 2: Patients in control g
Treatment - Drugs
Patients in intervention will receive 2 mcg/kg/min intravenous Alprostadil and Albuterol with 20 minutes interval in three dosages via inhalation.
Patients in control group will receive treatment based on their asthma attack severity. In mild to moderate attacks, patients will receive 2.5 mg Albuterol and 0.5 mg Ipratropium Bromide via inhalatio
Sponsors
Vice chancellor for research, Ahwaz Judishapur University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age range of 18 to 65 years; proved diagnosis of asthma based on primary outcomes (wheezing, cough, and breathlessness triad). Exclusion criteria: pulmonary diseases similar to asthma (such as interstitial lung disease)? having proven coagulation disorders and being treated with anticoagulants? history of chronic bronchitis; having acute medical disorders, cardiac, coronary vascular and arrhythmia diseases? being pregnant; treating with beta agonist nebulizers during last 6 hours, using cigarette more than 10 packs in year.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Forced expiratory volume in 1 second. Timepoint: Before intervention and in 20, 40, and 60 minutes after intervention. Method of measurement: Researcher-made questionnaire.;Peak expiratory flow rate. Timepoint: Before intervention and in 20, 40, and 60 minutes after intervention. Method of measurement: Researcher-made questionnaire.;Clinical symptoms severity. Timepoint: Before intervention and 40 minutes after intervention. Method of measurement: Researcher-made questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory rate. Timepoint: Before intervention and 40 minutes after intervention. Method of measurement: Researcher-made questionnaire.;Pulse rate. Timepoint: Before intervention and 40 minutes after intervention. Method of measurement: Researcher-made questionnaire.;Blood pressure rate. Timepoint: Before intervention and 40 minutes after intervention. Method of measurement: Researcher-made questionnaire.;Atrial oxygen saturation. Timepoint: Before intervention and 40 minutes after intervention. Method of measurement: Researcher-made questionnaire.;Level of consciousness. Timepoint: Before intervention and 40 minutes after intervention. Method of measurement: Researcher-made questionnaire.;Wheezing. Timepoint: Before intervention and 40 minutes after intervention. Method of measurement: Borg dyspnea scale.;Using respiratory peripheral muscles. Timepoint: Before intervention and 40 minutes after intervention. Method of measurement: Borg dyspnea scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzin Moradi
Ahvaz Jundishapur University of Medical Sciences
Outcome results
None listed