Comparison of nephrotoxicity of gentamicin and amikacin in the neonatal with infection

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016052828122N1

Enrollment

Registered

2016-12-19

Start date

2016-04-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention 1: Group 2: treated with ampicillin and gentamicin for 7 days. Intervention 2: Group 1: treated with ampicillin and amikacin for 7 days.

Treatment - Drugs

Group 2: treated with ampicillin and gentamicin for 7 days

Group 1: treated with ampicillin and amikacin for 7 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: infants hospitalized in Amir Kabir and Taleghani Hospital in Arak and has indicated treatment with an aminoglycoside antibiotic; Exclusion criteria: congenital kidney disease and urinary tract area such as Bartter, RTA or any renal tubular dysfunction, recent history of receiving nephrotoxic drugs (especially gentamicin and amikacin), congenital diseases and underlying Available Note, acid-base disturbance in ABG; edema and volume underlying disorder, disorder of the initial urine test markers before treatment

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
U/A. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;BUN. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;Creatinine. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;Sodium. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;Potassium. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;Blood calcium. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;Bicarbonate. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.	—

Measure

Time frame

U/A. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;BUN. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;Creatinine. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;Sodium. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;Potassium. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;Blood calcium. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.;Bicarbonate. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.

—

Secondary

Measure	Time frame
GFR. Timepoint: 8 days after starting antibiotic treatment. Method of measurement: Serum and urine samples.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Rafiei Yousof

Arak University Of Medical Sceinces

y.rafiei@arakmu.ac.ir+98 86 3313 7550

Outcome results