The effect of Scaling and Root Planning on level of TNF-alpha and IL-1alpha of saliva

Evaluation of IL-1alpha and TNF-alpha levels in saliva of patients with Chronic periodontitis before and after Scaling and Root Planing

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016052825649N3

Enrollment

Registered

2016-06-07

Start date

2016-02-09

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis. chronic periodontitis

Interventions

Intervention 1: Intervention group: Non-Surgical Treatment (Scaling and Root Planning). Intervention 2: Control group: observation.

Treatment - Other

Intervention group: Non-Surgical Treatment (Scaling and Root Planning)

Control group: observation

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria : Subjects with chronic periodontitis; Subjects with periodonta healthy; being healthy. Exclusion criteria : Subjects with systemic disorders (e.g.,diabetes mellitus, asthma); Pregnancy and Lactation; Having Less than 20 teeth; Use of antibiotics during last month; History of continuous consumption of NSATDs; Smoking , Alcohol abuse; History of periodontal treatments during one previous year; Subjects with inflammatory mucosal lesions (Lichen Planus) and Salivary gland disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Interleukin-1alpha. Timepoint: At the time of scaling and 30 days after it. Method of measurement: ELISA kit.;Tumor Necrosis Factor alpha. Timepoint: At the time of scaling and 30 days later. Method of measurement: ELISA kit.	—

Secondary

Measure	Time frame
Pocket depth. Timepoint: At the time of scaling and 30 days later. Method of measurement: measuring the distance of pocket base to the gingval margin using periodontal probe.;Clinical Attachment Loss. Timepoint: At the time of scaling and 30 days later. Method of measurement: measuring the distance of base of the pocket from CEJ.;Bleeding during Probing. Timepoint: At the time of scaling and 30 days later. Method of measurement: Observation.;Plaque Index. Timepoint: At the time of scaling and 30 days later. Method of measurement: Observation.	—

Measure

Time frame

Pocket depth. Timepoint: At the time of scaling and 30 days later. Method of measurement: measuring the distance of pocket base to the gingval margin using periodontal probe.;Clinical Attachment Loss. Timepoint: At the time of scaling and 30 days later. Method of measurement: measuring the distance of base of the pocket from CEJ.;Bleeding during Probing. Timepoint: At the time of scaling and 30 days later. Method of measurement: Observation.;Plaque Index. Timepoint: At the time of scaling and 30 days later. Method of measurement: Observation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Masoome Eivaz

Kermanshah Dentistry School

m.eivazi@kums.ac.ir+98 83 3722 2400

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026