end stage renal disease. Hypotension of hemodialysis
Conditions
Interventions
Intervention 1: synbiotic The synbiotic capsules (GeriLact brand
ZIST TAKHMIR Company, Tehran
Iran) contained Lactobacillus casei (3.5×109CFU), Lactobacillus acidophilus (1.5×109CFU), Lactobacillus rhamnosus (3×109CFU), Lactobacillus bulgaricus (3.5×108CFU), Bifidobacterium breve (5×109CFU), B
onecapsule per time), containing 1000mgsynbiotic. Intervention 2: placebo malto
1000mg).
Treatment - Drugs
Placebo
synbiotic The synbiotic capsules (GeriLact brand
onecapsule per time), containing 1000mgsynbiotic
placebo maltodextrin (2 capsules per day
Sponsors
Isfahan university of medical sciences; research assistant part
Food Safety Research Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: performing hemodialysis treatment 3-times per week for at least 4 hours each time, not being pregnant or lactating no history of active cancers (except for skin cancer) no history of severe chronic conditions such as pulmonary, cardiovascular, and hepatic diseases lack of gastrointestinal disorders, HIV disease, and psychiatric problems
Exclusion criteria
Exclusion criteria: those who used symbiotic, probiotic, prebiotic or antibiotics during 4 weeks preceding the study those who used immune suppressive medicines, and anticoagulant agents with severe edema addiction to alcohol or drugs abuse did not respond to the questions honestly and reported any side effects due to synbiotic consumption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Indoxyl sulfate. Timepoint: 1 and 8 weeks of treatment. Method of measurement: Eliza kit.;Crp. Timepoint: 1 and 8 weeks of treatment. Method of measurement: Eliza kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Phenol. Timepoint: 1 and 8 weeks of treatment. Method of measurement: hplc. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSoheila Mirzaeian
School of Nutrition and Food Sciences, Isfahan University of Medical Sciences
Outcome results
None listed