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The effect of Phenobarbital on the duration of hospitalization in non-hemolytic neonatal jaundice

The effect of Phenobarbital in various doses on the duration of hospitalization in non-hemolytic neonatal jaundice under phototherapy

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016052628090N1
Enrollment
90
Registered
2016-08-06
Start date
2014-08-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal jaundice. Neonatal jaundice, unspecified

Interventions

Intervention 1: Case group I: In addition to phototherapy, 10 mg/kg loading dose of phenobarbital was prescribed on first day followed by 5 mg/kg/day until the treatment of jaundice plus phototherapy.
Treatment - Drugs
Case group I: In addition to phototherapy, 10 mg/kg loading dose of phenobarbital was prescribed on first day followed by 5 mg/kg/day until the treatment of jaundice plus phototherapy.
Case group II: In addition to phototherapy, 3.5 mg/day phenobarbital was prescribedfrom day 1 until the treatment of jaundice plus phototherapy.
Control Group: Until the treatment of jaundice, Just received phototherapy.

Sponsors

Qazvin University of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Days to 5 Days

Inclusion criteria

Inclusion criteria: Inclusion criteria: Term neonate (> 37 weeks); Weight >= 2500 g; Indirect hyperbilirubinemia (Total bilirubin level: 17-20 mg/dL); Indication for phototherapy Exclusion criteria: Hemolysis from any cause; Metabolic and endocrine disorders; Genetic or chromosomal disorders; Sepsis; Blood transfusions; Any previous traditional drug therapy or phototherapy ; Vitamin K deficiency or bleeding in newborns; History of taking vitamin K by the mother during pregnancy; Discharge of infants with personal consent of parents before completion of treatment; Lack of parental consent for treatment or study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Total serum bilirubin levels. Timepoint: before, 24 and 48 hours after the initiation of treatment. Method of measurement: Blood test.;Duration of hospitalization. Timepoint: Discharge time. Method of measurement: Patient file.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNafiseh Ataie

Qazvin University of Medical Science

dr.nafiseh.ataie@gmail.com+98 28 3333 4807

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026