Diabetes mellitus Type 2. Diabetes mellitus
Conditions
Interventions
Intervention 1: Group 1 (intervention group) consume 6 capsules of 100 mg of sodium butyrate capsules and 5 mg starch powder as placebo for 6 weeks with meals daily. Intervention 2: Group 2 consume in
Treatment - Drugs
Group 1 (intervention group) consume 6 capsules of 100 mg of sodium butyrate capsules and 5 mg starch powder as placebo for 6 weeks with meals daily.
Group 2 consume inulin powder (chicory root extract) 10 g and 6 starch capsules 500 mg as placebo per day for 6 weeks.
Group 3 devoted to the concomitant use of inulin powder and capsules sodium butyrate (10 g inulin powder and sodium butyrate 6 capsules 100 mg) for 6 weeks.
Group 4 (control group) consume 6 capsules 500 mg starch as well as 5 mg starch powder as placebo for 6 weeks.
Sponsors
Vice-Chancellor for Research of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 50 Years
Inclusion criteria
Inclusion criteria: Major inclusion criteria included a diagnosis of type 2 diabetes; aged 30 to 50years; range 27 <BMI <35 Major exclusion criteria included: kidney problems; liver failure; heart failure; rheumatic diseases and inflammatory diseases of the gastrointestinal tract; insulin injections and drugs; estrogen; progesterone ; taking vitamin supplements; minerals; omega-3 and antibiotics for three weeks before the study
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Txnip Gene. Timepoint: Before & after intervention. Method of measurement: Real-time PCR.;Level of GLP-1. Timepoint: Before & after intervention. Method of measurement: Elisa test.;Levels of mir-204. Timepoint: Before & after intervention. Method of measurement: Real-time PCR.;Levels of mir-200c. Timepoint: Before & after intervention. Method of measurement: Real-time PCR.;Levels of mir-21. Timepoint: Before & after intervention. Method of measurement: Real-time PCR. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose. Timepoint: before & after intervention. Method of measurement: Enzymatic assay.;Blood sugar 2 hpp. Timepoint: before & after intervention. Method of measurement: Enzymatic assay.;Fasting Insulin. Timepoint: before & after intervention. Method of measurement: Elisa.;HbA1C. Timepoint: before & after intervention. Method of measurement: Kit.;Lipid profile. Timepoint: before & after intervention. Method of measurement: Enzymatic assay.;Energy and macronutrients. Timepoint: before & after intervention. Method of measurement: 3 days recall.;Abundance of Akkermansia muciniphila bacteria in stool samples. Timepoint: before & after intervention. Method of measurement: colony count. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNeda Roshanravan
Tabriz university of Medical Sciences
Outcome results
None listed