Therapeutic effect of heated, humidified, high-flow nasal cannula (HHHFNC) in respiratory distress syndrome

Therapeutic effect of heated, humidified, high-flow nasal cannula (HHHFNC) and Nasal intermittent mandatory ventilation (NIMV) as initial therapy of respiratory distress syndrome (RDS) in very Low Birth Weight (VLBW) Infants

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016052510026N7

Enrollment

Registered

2017-07-08

Start date

2017-01-09

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory distress syndrome. Respiratory distress syndrome of newborn

Interventions

Intervention 1: For infants in early-NIMV group (non-synchronized mode), NIMV will set at peak inspiratory pressure (PIP) of 16 -20 cmH2O (according to infant’s birth weight and chest wall expansion),

Treatment - Devices

Treatment - Drugs

For infants in early-NIMV group (non-synchronized mode), NIMV will set at peak inspiratory pressure (PIP) of 16 -20 cmH2O (according to infant’s birth weight and chest wall expansion), positive end e

For infants in HHHFNC group, high flow was initiated with a flow of 2.5-3 L/minute by a short bi-nasal prongs. Setting was adjusted according to arterial blood gases (ABG), clinical parameters and to

Eligibility

Sex/Gender

All

Age

No minimum to 1 Months

Inclusion criteria

Inclusion criteria: Inclusion criteria: premature infants, weighing less than 1500 g and RDS symptoms requires treatment. Exclusion criteria: are major congenital anomalies; respiratory anomalies; orofacial malformations and cyanotic heart diseases.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The duration of non-invasive respiratory support. Timepoint: at the 3th and 7th days of life. Method of measurement: Daily recorded sheets.	—

Secondary

Measure	Time frame
Time to full enteral feeds. Timepoint: at the 3th, 7th and 15th days of life. Method of measurement: Daily recorded sheets.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mahdi Parvaneh

Isfahan University of Medical Sciences

Drmparvaneh@gmail.com+98 31 3337 8059

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026