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Indomethacin and fertility outcomes in infertile women with poor ovarian response

Comparison of the effect of indomethacin compared to not receiving indomethacin on fertility outcomes in infertile women with poor ovarian response under assisted reproductive treatment

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160524028038N12
Enrollment
60
Registered
2022-12-02
Start date
2022-11-26
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility due to poor ovarian response. Female infertility of other origin

Interventions

Intervention 1: First, patients will receive 300 units of Gonal F ampoule and 150 units of human monoposal gonadotropin daily for 4 days from the second day of menstruation. Gonadotropin dose will be

Sponsors

Bandare-abbas University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patients aged 18 to 45 years Absence of contraindications to the use of indomethacin Normal semen analysis poor ovarian response

Exclusion criteria

Exclusion criteria: Patients with other endocrine disorders such as hyperprolactinemia, PCOS, etc. History of ovarian surgery or ovarian endometrioma Smoker Cardiovascular disorders Receiving drugs affecting the metabolism of indomethacin Unwillingness to cooperate History of peptic ulcer or recurrent active gastric ulcer History of gastrointestinal lesions Allergy to indomethacin or any of the ingredients of this product History of acute attacks of asthma, urticaria, or rhinitis as a result of treatment with aspirin or other non-steroidal anti-inflammatory drugs. Drug abuse History of proctitis or recent rectal bleeding Having nasal polyps with angioneurotic edema

Design outcomes

Primary

MeasureTime frame
Oocyte Quality. Timepoint: 2-3 hrs. after oocyte collection. Method of measurement: Microscopic Evaluation.;Number of retried oocyte. Timepoint: On day of oocyte retrieval. Method of measurement: Counting number of total oocytes with microscope.;Number of embryo. Timepoint: On the 2nd day after ICSI. Method of measurement: Observation with microscope.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAssociate professor

Bandare-abbas University of Medical Sciences

maryamazizikut86@gmail.com076333666365

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026