The Effect of of Aerobic with Breathing Exercises on Physical-Psychological Symptoms in Patients with Mitral Valve Prolapse

The Effect of Twelve Weeks of Aerobic with Breathing Exercises on Physical-Psychological Symptoms, Functional Capacity (VO2peak), and Hemodynamic Indicators in Patients with Mitral Valve Prolapse

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160523028028N4

Enrollment

Registered

2025-01-06

Start date

2025-03-02

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mitral Valve Prolapse. Nonrheumatic mitral (valve) prolapse

Interventions

Intervention 1: Intervention group: Engage in 12 weeks of combined aerobic and breathing exercise training, three days a week for 45 to 70 minutes. The intensity of the workout will be adjusted based

Eligibility

Sex/Gender

Female

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: History of mitral valve prolapse for over three years Mild to moderate mitral regurgitation Normal ventricular function

Exclusion criteria

Exclusion criteria: History of stroke, panic attacks, hypertension, mental or cognitive disorders, or valve replacement or repair surgery. Having other major cardiovascular diseases, respiratory diseases, and diabetes Pregnancy.

Design outcomes

Primary

Measure	Time frame
Sleep quality. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: Petersburg Sleep Questionnaire (PSQI).;Fatigue. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: Daily fatigue questionnaire (Multidimensional Fatigue Inventory).;Peak VO2. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: 6-minute walk test(6MWT).;Resting systolic and diastolic blood pressure. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: Omron M3 digital blood pressure monitor.;Peak systolic and diastolic blood pressure. Timepoint: Before and after 12 weeks of training protocol immediately after the 6MWt test. Method of measurement: Omron M3 digital blood pressure monitor.;Rest Heart rate. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: Omron M3 digital blood pressure monitor.;Peak Heart Rate. Timepoint: Before and after 12 weeks of training protocol immediately after the 6MWt test. Method of measurement: Omron M3 digital blood pressure monitor.;Rest Rate Pressure Product. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: Defined by resting heart rate (RHR) multiplied by systolic blood pressure (SBP).;Peak Rate Pressure Product. Timepoint: Before and after 12 weeks of training protocol immediately after the 6MWt test. Method of measurement: Defined by peak heart rate multiplied by systolic blood pressure (SBP).	—

Measure

Time frame

Sleep quality. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: Petersburg Sleep Questionnaire (PSQI).;Fatigue. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: Daily fatigue questionnaire (Multidimensional Fatigue Inventory).;Peak VO2. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: 6-minute walk test(6MWT).;Resting systolic and diastolic blood pressure. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: Omron M3 digital blood pressure monitor.;Peak systolic and diastolic blood pressure. Timepoint: Before and after 12 weeks of training protocol immediately after the 6MWt test. Method of measurement: Omron M3 digital blood pressure monitor.;Rest Heart rate. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: Omron M3 digital blood pressure monitor.;Peak Heart Rate. Timepoint: Before and after 12 weeks of training protocol immediately after the 6MWt test. Method of measurement: Omron M3 digital blood pressure monitor.;Rest Rate Pressure Product. Timepoint: Before and after 12 weeks of training protocol. Method of measurement: Defined by resting heart rate (RHR) multiplied by systolic blood pressure (SBP).;Peak Rate Pressure Product. Timepoint: Before and after 12 weeks of training protocol immediately after the 6MWt test. Method of measurement: Defined by peak heart rate multiplied by systolic blood pressure (SBP).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzam Zarneshan

Azarbaijan Shahid Madani University

zarneshan@azaruniv.ac.ir+98 41 3145 2407

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026