Comparative study of response to treatment and recurrence of brucellosis in the 4 and 6 week treatment groups with doxycycline, streptomycin and hydroxychloroquine.

Comparative study of response to treatment and recurrence of brucellosis in the 4 and 6 week treatment groups with doxycycline, streptomycin and hydroxychloroquine. A single blinded randomised clinical trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160523028008N4

Enrollment

102

Registered

2019-07-02

Start date

2019-02-20

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brucellosis. Brucellosis

Interventions

Intervention 1: Intervention group: Doxycycline - Streptomycin (4 weeks doxycycline, 3 weeks streptomycin) plus hydroxy chloroquine 400 mg daily for 4 weeks. Intervention 2: Control group: Doxycycli

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: patients with sign and symptoms of brucellosis have Wright test of more than 1/160 and 2ME titer more than 1/80 Age of 18 years or older Consent to participate in the study

Exclusion criteria

Exclusion criteria: being pregnant Chronic Illnesses Any serious complication of brucellosis

Design outcomes

Primary

Measure	Time frame
Response to treatment. Timepoint: at 1, 4, and 6 months after treatment. Method of measurement: through history taking and physical examination.;Recurrence. Timepoint: 4 and 6 months after treatmen. Method of measurement: Recurrence of the patient's clinical symptoms.	—

Secondary

Measure	Time frame
Incidence of probable adverse effects such as hepatitis and visual impairment. Timepoint: at 1, 4, and 6 months after treatment. Method of measurement: through history taking and physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammad Mahdi Majzoobi

Hamedan University of Medical Sciences

mahdi.majzoobi@umsha.ac.ir+98 81 3838 0717

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026