Respiratory distress syndrome. Respiratory distress syndrome of newborn
Conditions
Interventions
Intervention 1: Intervention group: Nasal Continuous Positive Airway Pressure (nCPAP) at higher level of 9 cmH2O. Infants receive nCPAP at 9 cmH2O immediately after extubation via nasal prongs or mask
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 1 Months
Inclusion criteria
Inclusion criteria: Gestational age =32 weeks Receiving mechanical ventilation via endotracheal tube First-time extubation to nCPAP Receipt of exogenous surfactant (if indicated per clinical protocol) Written informed consent obtained from parents or legal guardian
Exclusion criteria
Exclusion criteria: Major congenital anomaly Congenital heart disease (excluding ASD and PDA) Evidence of necrotizing enterocolitis (NEC) prior to surfactant administration Chromosomal disorders (e.g., Trisomy 13, 18, 21) Heart failure requiring treatment (inotropes or vasopressors)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extubation failure. Timepoint: Within 96 hours after extubation. Method of measurement: Clinical examination and event recording. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reintubation within 7 days after extubation. Timepoint: 7 days (168 hours) after extubation. Method of measurement: Clinical examination and medical record review. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFershthe Hajipour
Hamedan University of Medical Sciences
Outcome results
None listed