The effect of adding omega-3 in bipolar patients during manic period requiring ECT.

The effectiveness of omega-3 adjuvant therapy to Electroconvulsive therapy (ECT) in bipolar patients in a manic episode

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160523028008N26

Enrollment

Registered

2022-09-13

Start date

2022-08-23

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bipolar Disorder, current episode manic severe with psychotic features. Bipolar Disorder, current episode manic severe with psychotic features

Interventions

Intervention 1: Intervention group: 25 patients with bipolar disorder in the mania phase are treated with electroshock therapy with 100 mg omega-3 capsules (manufactured by Zahravi company) as a singl

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Bipolar patients in the acute phase of mania who, according to the physician, needed ECT Age greater than or equal to 18 Young Mania Rating Scale greater than or equal to 20 Having at least fifth grade education

Exclusion criteria

Exclusion criteria: Psychiatric disorders except Bipolar Disorder Pregnancy or breastfeeding Having a history of substance abuse in the last 2 weeks or addiction in the last 2 months Having a systemic disease

Design outcomes

Primary

Measure	Time frame
Mania symptoms. Timepoint: Before the intervention, after the fourth and eighth sessions of ECT. Method of measurement: Young Mania Rating Scale (YMRS).;Cognitive function. Timepoint: Before and after the intervention. Method of measurement: Cognitive function Test by using Montreal Cognitive Assessment.;Sleep quality. Timepoint: Before and after the intervention. Method of measurement: Pittsburgh Sleep Quality Index.	—

Measure

Time frame

Mania symptoms. Timepoint: Before the intervention, after the fourth and eighth sessions of ECT. Method of measurement: Young Mania Rating Scale (YMRS).;Cognitive function. Timepoint: Before and after the intervention. Method of measurement: Cognitive function Test by using Montreal Cognitive Assessment.;Sleep quality. Timepoint: Before and after the intervention. Method of measurement: Pittsburgh Sleep Quality Index.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKhadijeh Arabloo

Hamedan University of Medical Sciences

Kharabloo1358@gmail.com+98 81 1828 5015

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026