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Evaluation of effectiveness of different dosage neostigmine in combination with metoclopramide on gastric residual volume

Evaluation of effectiveness different dosage neostigmine in combination with metoclopramide on gastric residual volume, in enteral nutrition, in hospitalized patients who are in ICU.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160523028008N21
Enrollment
132
Registered
2022-02-19
Start date
2022-03-16
Completion date
Unknown
Last updated
2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dilatation of volume. Acute dilatation of stomach

Interventions

Intervention 1: Intervention group: Metoclopramide, manufactured by Caspian Tamin Pharmaceutical Company, at a dose of 20 mg / 100 ml of normal saline, intravenously and one time. Intervention 2: Inte

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age between 20 and 60 years tube Patients under mechanical ventilation Patients with enteral nutrition through nasogastric

Exclusion criteria

Exclusion criteria: Previous use of beta-blockers Heart Block Bradycardia heart rate less than 60)before inclusion Hypothermia in the form of central temperature below 35 degrees Kidney Failure (CR> 1.5) Extra Recent surgery on stomach or digestive tract within the last ten days Signs and symptoms of bowel obstruction Pregnancy and lactation Active Sensitivity to Neostigmine

Design outcomes

Primary

MeasureTime frame
Gastric residual volume. Timepoint: Before starting the drug infusion and 3, 6, 9 and 12 hours after the start of the infusion. Method of measurement: Aspirate with a gavage syringe.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Moshari

Shahid Beheshti University of Medical Sciences

Rmoshari@sbmu.ac.ir+98 21 2243 2595

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026