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The effect of antibiotics on reducing infection

Evaluation of the effect of oral metronidazole and cefixime as prophylaxis in uncomplicated appendicitis in comparison with ceftriaxone and metronidazole injection

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160523028008N12
Enrollment
200
Registered
2021-02-25
Start date
2021-04-20
Completion date
Unknown
Last updated
2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute appendicitis. Acute appendicitis

Interventions

Intervention 1: Intervention group: Metronidazole 500 mg with cefixime 400 mg orally. Intervention 2: Control group:Metronidazole 500 mg and one gram of ceftriaxone both injectable.

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
10 Years to 75 Years

Inclusion criteria

Inclusion criteria: patients are who were operated with clinical diagnosis of appendicitis's.

Exclusion criteria

Exclusion criteria: Patients with complicated appendicitis (perforated and peritonitis The underlying diseases (diabetes mellitus, acquired or intrinsic Immunodeficiency) immunosuppressive drugs inability to follow patients

Design outcomes

Primary

MeasureTime frame
Purulent discharge of the wound. Timepoint: 3,7 days, one month and three months after surgery. Method of measurement: Visual secretion.;Pain at the wound site. Timepoint: 3,7 days, one month and three months after surgery. Method of measurement: asking the patient.;Warmth in the wound. Timepoint: 3,7 days, one month and three months after surgery. Method of measurement: Visual examination of the patient.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKhosro Ayazi

Behbahan University of Medical Sciences

kh-ayazi@gmail.com+98 21 2387 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026