Cryptogenic cirrhosis. Other and unspecified cirrhosis of liver
Conditions
Interventions
Intervention 1: control group: traditional conservative treatments. Intervention 2: Intervention group: traditional conservative treatments + infliximab (loading dose: 3 mg/kg & maintenance dose: 3 mg
q 2 weeks).
Treatment - Other
Treatment - Drugs
control group: traditional conservative treatments
Intervention group: traditional conservative treatments + infliximab (loading dose: 3 mg/kg & maintenance dose: 3 mg/kg for 12 weeks
q 2 weeks)
Sponsors
Research center for infectious diseases of digestive system, research adjutancy of Ahvaz Jundishapur
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: existence of proved cryptogenic cirrhosis; lack of experience with infliximab treatment in cirrhosis due to it; having informed consent Exclusion criteria: Decompensated cirrhosis; active or latent tuberculosis; patient's trend to leaving the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of MELD score. Timepoint: 0- 3th month- 6th month. Method of measurement: according to creatinine, billirubine, and INR- Range: 6-40. | — |
Secondary
| Measure | Time frame |
|---|---|
| Decrease of numbers of hospitalization and decrease of cirrhosis complications. Timepoint: 0- 3th month- 6th month. Method of measurement: Evaluation of patient's medical file and disease progression. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSanaz Taherpour
Ahvaz Jundishapur University of Medical Sciences
Outcome results
None listed