Helicobacter pylori. Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters
Conditions
Interventions
Intervention 1: The experimental group was given amoxicillin (capsules, 1000?mg) bid (with breakfast and dinner), clarithromycin (capsules, 500?mg) bid (with breakfast and dinner), and omeprazole (cap
Treatment - Drugs
The experimental group was given amoxicillin (capsules, 1000?mg) bid (with breakfast and dinner), clarithromycin (capsules, 500?mg) bid (with breakfast and dinner), and omeprazole (capsules, 20?mg) bi
(The control group was given amoxicillin/clarithromycin/omeprazole the same as experimental group, plus placebo.In patients without peptic ulcer, omeprazole 20?mg once daily was continued for 2 weeks.
Sponsors
Vice chancellor for research of Guilan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: All patients with peptic-like epigastric pain and dyspeptic symptoms, referred to the endoscopy unit and scheduled for upper GI endoscopy and with positive rapid urease test Exclusion criteria: age70, recent use of antibiotics, bismuth salts, or proton pump inhibitors (PPI), chronic use of nonsteroidal anti-inflammatory drugs or corticosteroids, gastric outlet obstruction, pregnancy, renal failure, gastric malignancy, and prior gastric surgery
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradocation of Helicobacter pylori. Timepoint: before initiate Intervention, two wk after finishing the intervention. Method of measurement: Urease breath test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: before initiating intervention, 2 wk after finishing the intervention. Method of measurement: physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarahnaz Joukar
Gastrointestinal and Liver Disease Research Center(GLDRC)
Outcome results
None listed