Effect of three-drug regimen against H. pylori infection versus four-drug regiment in patients with dyspepsia or peptic ulcer disease

Effect of three-drug regimen against H. pylori infection versus four-drug regiment in patients with dyspepsia or peptic ulcer disease: a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201605189014N100

Enrollment

150

Registered

2016-06-08

Start date

2016-06-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyspepsia. Dyspepsia

Interventions

Intervention 1: Intervention group 1: Capsule Omeprazole 20 mg twice a day and capsule Amoxicillin 1000 mg twice a day and capsule clarithromycin 500 mg twice a day for 14 days. Intervention 2: Interv

Treatment - Drugs

Intervention group 1: Capsule Omeprazole 20 mg twice a day and capsule Amoxicillin 1000 mg twice a day and capsule clarithromycin 500 mg twice a day for 14 days.

Intervention group 2: Capsule Omeprazole 20 mg twice a day and capsule Amoxicillin 1000 mg twice a day and capsule Levofloxacin 500 mg twice a day for 14 days.

Control group: Capsule Omeprazole 20 mg twice a day and capsule Amoxicillin 1000 mg twice a day and tablet Metronidazole 500 mg twice a day and tablet Bismuth 240 mg twice a day for14 days.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: dyspepsia for at least 3 months; H. pylori infection, age of 18 to 70 years. Exclusion criteria: pregnancy or breastfeeding; history of surgery of upper stomach or bowel; gastric cancer; renal or lever failure.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Assessing the irradiation of H. pylori infection. Timepoint: 4 to 6 weeks after treatment. Method of measurement: using urease respiratory test with labeled carbon.	—

Secondary

Measure	Time frame
Nothing. Timepoint: Nothing. Method of measurement: Nothing.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Anvar Bahrami

Shahid Beheshti Hospital

med5921@gmail.com+98 81 3838 0283

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026