Burn. Burns and corrosions of external body surface
Conditions
Interventions
Intervention 1: Intervention group: 3 minutes before daily changing the wound dressing, 50 microgram Fentanyl (Dorsa Darou) plus 2 miligram Midazolam (Dorsa Darou) will be infused intravenously .All
Treatment - Drugs
Placebo
Intervention group: 3 minutes before daily changing the wound dressing, 50 microgram Fentanyl (Dorsa Darou) plus 2 miligram Midazolam (Dorsa Darou) will be infused intravenously .All patients receive
Placebo group: 5 cc strilled water in the same 5 cc syringe will be infused intravenously.
All patients receive 5 mg morphine sulfate intravenously 10-15 minutes before changing dressing . All pati
Sponsors
Vice chancellor for research of Yazd Shahid Sadoughi University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Patients aged 16-55 years with second degree thermal burn; require daily dressing change; being in second day of admission; having at least one wound larger than 5 % of body surface area; signing informed consent. Exclusion Criteria: affected by chronic disease (Diabetes mellitus, cardiovascular disease, Hepatic disease, Renal disease); Immune deficiency( corticosteroid, chemotherapy); history of anaphilaxys to sedation drugs, Opiates, benzodiazepines; difficult airway according to mallampati score; history of opiates addiction
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound repair score. Timepoint: every 2 weeks from week zero till 12th week. Method of measurement: Vancover score.;Time to healing. Timepoint: every 2 weeks from week 1 till 12th week. Method of measurement: According to clinical judgment of plastic surgeon regarding discharge, pain or redness of the burned area. When plastic surgeon confirms clinical healing, that time is documented as the healing time. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score. Timepoint: 5 minutes before and after changing dressing every 2 weeks from week zero till 12th week. Method of measurement: Visual Analogue Scale.;Wound infection. Timepoint: daily in first week then on 14th day. Method of measurement: According to clinical judgment of plastic surgeon regarding discharge and erythema of wound. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSima Valizadeh
Yazd Shahid Sadoughi University of Medical Sciences
Outcome results
None listed