The effect of lipoic acid supplementation on stroke patients

The effect of alpha-lipoic acid supplementation on some cardiovascular indicators, inflammatory markers, and lipid profile in patients with stroke

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016051811763N23

Enrollment

Registered

2016-06-29

Start date

2016-05-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

strok. Stroke, not specified as haemorrhage or infarction

Interventions

Intervention 1: lipoic acid 600 mg. Intervention 2: corn starch 600 mg.

Treatment - Drugs

Placebo

lipoic acid 600 mg

corn starch 600 mg

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with thrombotic and embolic stroke ; NIHS Score = 5-24 ; age 30 to 70 years; BMI in the range of 18.5-35. exclusion criteria: unwillingness to continue; recurrent stroke during the study; death.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Carotid intima media thickness. Timepoint: Before and 12 weeks after intervention. Method of measurement: sonography doppler.;Flow mediated dilation. Timepoint: Before and 12 weeks after intervention. Method of measurement: sonography doppler.;TNF-a. Timepoint: Before and 12 weeks after intervention. Method of measurement: ELISA.;IL-6. Timepoint: Before and 12 weeks after intervention. Method of measurement: ELISA.;Hs-CRP. Timepoint: Before and 12 weeks after intervention. Method of measurement: ELISA.;TG. Timepoint: Before and 12 weeks after intervention. Method of measurement: kit.;Total cholesterol. Timepoint: Before and 12 weeks after intervention. Method of measurement: Enzymatic.;LDL. Timepoint: Before and 12 weeksafter intervention. Method of measurement: Friedewald.;HDL. Timepoint: Before and 12 weeks after intervention. Method of measurement: Spectrophotometry.;Fasting blood glucose. Timepoint: Before and 12 weeks after intervention. Method of measurement: Spectrophotometry.;Fasting insulin. Timepoint: Before and 12 weeks after intervention. Method of measurement: ELISA.;Systolic blood pressur. Timepoint: Before and 12 weeks after intervention. Method of measurement: Mercury manometers.;Diastolic blood pressur. Timepoint: Before and 12 weeks after intervention. Method of measurement: Mercury manometer.	—

Measure

Time frame

Carotid intima media thickness. Timepoint: Before and 12 weeks after intervention. Method of measurement: sonography doppler.;Flow mediated dilation. Timepoint: Before and 12 weeks after intervention. Method of measurement: sonography doppler.;TNF-a. Timepoint: Before and 12 weeks after intervention. Method of measurement: ELISA.;IL-6. Timepoint: Before and 12 weeks after intervention. Method of measurement: ELISA.;Hs-CRP. Timepoint: Before and 12 weeks after intervention. Method of measurement: ELISA.;TG. Timepoint: Before and 12 weeks after intervention. Method of measurement: kit.;Total cholesterol. Timepoint: Before and 12 weeks after intervention. Method of measurement: Enzymatic.;LDL. Timepoint: Before and 12 weeksafter intervention. Method of measurement: Friedewald.;HDL. Timepoint: Before and 12 weeks after intervention. Method of measurement: Spectrophotometry.;Fasting blood glucose. Timepoint: Before and 12 weeks after intervention. Method of measurement: Spectrophotometry.;Fasting insulin. Timepoint: Before and 12 weeks after intervention. Method of measurement: ELISA.;Systolic blood pressur. Timepoint: Before and 12 weeks after intervention. Method of measurement: Mercury manometers.;Diastolic blood pressur. Timepoint: Before and 12 weeks after intervention. Method of measurement: Mercury manometer.

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Secondary

Measure	Time frame
Carotenoids intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Weight. Timepoint: before and 12 weeks after intervention. Method of measurement: seca balance.;Waist circumference. Timepoint: before and 12 weeks after intervention. Method of measurement: tape.;Energy intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Carbohydrate intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Fat intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Protein intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Vitamin E intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Vitamin C intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.	—

Measure

Time frame

Carotenoids intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Weight. Timepoint: before and 12 weeks after intervention. Method of measurement: seca balance.;Waist circumference. Timepoint: before and 12 weeks after intervention. Method of measurement: tape.;Energy intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Carbohydrate intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Fat intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Protein intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Vitamin E intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.;Vitamin C intake. Timepoint: before and 12 weeks after intervention. Method of measurement: 24 food recall.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactVida Mohammadi

Isfahan University of Medical Sciences

Mohammadi_vida@yahoo.com+98 31 3792 3171

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026