cronary artery disease. Other forms of acute ischaemic heart disease
Conditions
Interventions
Intervention 1: Intervention: 300 mg thiamin in 500 cc normal saline prior to initiation of surgery. Intervention 2: Control: 500 cc normal saline prior to initiation of surgery.
Treatment - Drugs
Intervention: 300 mg thiamin in 500 cc normal saline prior to initiation of surgery.
Control: 500 cc normal saline prior to initiation of surgery
Sponsors
Deputy for research and thecnology, Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients candidate for CABG; Ejection fraction 45-55 %; no sensitivity to thiamin; no alcohol dependency. Exclusion criteria: renal or liver failure; CNS complications; post-surgical infections or massive hemorrhage.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of lactate. Timepoint: prior to surgery, every 2 hour during the surgery, 6, 12, 18 and 24 hour after surgery. Method of measurement: laboratory assessment of serum level of lactate.;Ejection fraction. Timepoint: prior to and 24 hour after surgery. Method of measurement: echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum level of creatinin. Timepoint: prior to, every 2 hour during the surgery, 6, 12, 18, 24 hour after surgery. Method of measurement: mg/dl.;ABG. Timepoint: prior to, every 2 hour during the surgery, 6, 12, 18, 24 hour after surgery. Method of measurement: %.;Inotrope consumption. Timepoint: during the surgry until 24 h after. Method of measurement: microgram. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Alireza Jahangirifard
Shahid Beheshti University of Medical Sciences.
Outcome results
None listed