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Pain of Propofol Intravenous Injection

The Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016051410340N10
Enrollment
80
Registered
2016-07-01
Start date
2015-03-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain. Pain in limb

Interventions

Intervention 1: 40 mg Lidocaine was intravenously administered as a premedication before propofol injection. Intervention 2: 25 mg Ketamine was intravenously administered as a premedication before pro
Prevention
40 mg Lidocaine was intravenously administered as a premedication before propofol injection
25 mg Ketamine was intravenously administered as a premedication before propofol injection
1 gr Magnesium sulfate was intravenously administered as a premedication before propofol injection
5 ml Normal saline was intravenously administered as a premedication before propofol injection

Sponsors

Golestan University of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: people aged 18-65 years that categorized into class 1 and 2 based on America Society of Anesthesiologists (ASA); hypertension between 90 and 140 until 24 hours before surgery; lack of neurological disorders, kidney and liver failure; lack of drug allergy; no history of allergy to eggs or anaphylaxis. Exclusion criteria were considered as: having allergies or symptoms of heart disease and arrhythmias; saturation drops below 90%; operation duration more than 3 hours.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: After intervention. Method of measurement: Verbal Rating Scale.

Secondary

MeasureTime frame
Hemodynamic Change. Timepoint: Before Intervention, 1,3 and 5 minutes after intervention. Method of measurement: Sphygmomanometer, Pols oximeter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHomeira Khodam

Golestan University of Medical Science

homeira_khoddam@yahoo.com+98 17 3242 4377

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026